Aberrant Time-Varying Cross-Network Interactions in Children With Attention-Deficit/Hyperactivity Disorder and the Relation to Attention Deficits

Biological Psychiatry : Cognitive Neuroscience and Neuroimaging
Weidong CaiVinod Menon

Abstract

Attention-deficit/hyperactivity disorder (ADHD) is thought to stem from aberrancies in large-scale cognitive control networks. However, the exact nature of aberrant brain circuit dynamics involving these control networks is poorly understood. Using a saliency-based triple-network model of cognitive control, we tested the hypothesis that dynamic cross-network interactions among the salience, central executive, and default mode networks are dysregulated in children with ADHD, and we investigated how these dysregulations contribute to inattention. Using functional magnetic resonance imaging data from 140 children with ADHD and typically developing children from two cohorts (primary cohort = 80 children, replication cohort = 60 children) in a case-control design, we examined both time-averaged and dynamic time-varying cross-network interactions in each cohort separately. Time-averaged measures of salience network-centered cross-network interactions were significantly lower in children with ADHD compared with typically developing children and were correlated with severity of inattention symptoms. Children with ADHD displayed more variable dynamic cross-network interaction patterns, including less persistent brain states, significant...Continue Reading

References

Jun 1, 1992·Journal of Abnormal Child Psychology·S M Alessandri
Jan 1, 1996·Journal of Child Psychology and Psychiatry, and Allied Disciplines·B F Pennington, S Ozonoff
Sep 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·E E Smith, J Jonides
Mar 22, 2001·Proceedings of the National Academy of Sciences of the United States of America·D A GusnardM E Raichle
May 8, 2002·Nature Reviews. Neuroscience·Maurizio Corbetta, Gordon L Shulman
Aug 3, 2002·Nature Reviews. Neuroscience·F Xavier Castellanos, Rosemary Tannock
Dec 31, 2002·Proceedings of the National Academy of Sciences of the United States of America·Michael D GreiciusVinod Menon
Mar 26, 2004·Cognitive, Affective & Behavioral Neuroscience·Tor D Wager, Edward E Smith
Aug 4, 2004·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Susan Homack, Cynthia A Riccio
Oct 27, 2004·Journal of the American Academy of Child and Adolescent Psychiatry·Leanne TammAllan L Reiss
Jun 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Michael D FoxMarcus E Raichle
Aug 25, 2005·Psychological Medicine·A Marije BoonstraJan K Buitelaar
Dec 15, 2005·Journal of Abnormal Psychology·Joel T NiggJohn M Henderson
Dec 24, 2005·Journal of Attention Disorders·Stephen V Faraone, Joseph Biederman
May 30, 2006·Neuron·Nico U F DosenbachSteven E Petersen
Jun 30, 2006·Biological Psychiatry·Christoph KleinMartin Peper
Nov 1, 2006·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Steven G DicksteinMichael P Milham
Mar 3, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·William W SeeleyMichael D Greicius
Apr 4, 2007·Neuropsychology·Marieke M LansbergenHerman van Engeland
Apr 21, 2007·Neuroscience and Biobehavioral Reviews·Edmund J S Sonuga-Barke, F Xavier Castellanos
Jun 2, 2007·The American Journal of Psychiatry·Guilherme PolanczykLuis Augusto Rohde
Aug 2, 2007·Journal of Abnormal Child Psychology·R Matt AldersonMichael J Kofler
Aug 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Devarajan SridharanVinod Menon
Apr 18, 2009·Developmental Neuroscience·Nikos MakrisLarry J Seidman
Mar 17, 2010·NeuroImage·Pierre BellecAlan C Evans
Jun 1, 2010·Brain Structure & Function·Vinod Menon, Lucina Q Uddin
Jul 3, 2010·The American Journal of Psychiatry·Thomas InselPhilip Wang
Mar 4, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Robert LeechDavid J Sharp
Jul 20, 2011·Current Topics in Behavioral Neurosciences·Jonna Kuntsi, Christoph Klein
Sep 13, 2011·Trends in Cognitive Sciences·Vinod Menon
Nov 22, 2011·Neuron·Jonathan D PowerSteven E Petersen
Dec 16, 2011·Trends in Cognitive Sciences·F Xavier Castellanos, Erika Proal
Sep 18, 2012·The American Journal of Psychiatry·Samuele CorteseF Xavier Castellanos
Apr 11, 2013·Nature Reviews. Neuroscience·Katherine S ButtonMarcus R Munafò

❮ Previous
Next ❯

Citations

Dec 28, 2018·Brain and Behavior·Blair UniackeJoanna Steinglass
Mar 8, 2019·PloS One·Samuel P LeightonAndrew I Gumley
Jun 17, 2020·Cerebral Cortex·Xuyun WenDinggang Shen
Jun 21, 2019·Brain Imaging and Behavior·Virginia de Oliveira RosaLuis Augusto Paim Rohde
Dec 7, 2021·Frontiers in Systems Neuroscience·Katherine G WarthenBrian J Mickey

❮ Previous
Next ❯

Related Concepts

Related Feeds

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.

Brain Lower Grade Glioma

Low grade gliomas in the brain form from oligodendrocytes and astrocytes and are the slowest-growing glioma in adults. Discover the latest research on these brain tumors here.