Aberrant topological organization of the functional brain network associated with prior overt hepatic encephalopathy in cirrhotic patients

Brain Imaging and Behavior
Hua-Jun ChenHai-Bin Shi

Abstract

A higher risk of cognitive impairments has been found after an overt hepatic encephalopathy (OHE) episode in cirrhotic patients. We investigated the effect of prior OHE episodes on the topological organization of the functional brain network and its association with the relevant cognitive impairments. Resting-state functional MRI data were acquired from 41 cirrhotic patients (19 with prior OHE (Prior-OHE) and 22 without (Non-Prior-OHE)) and 21 healthy controls (HC). A Psychometric Hepatic Encephalopathy Score (PHES) assessed cognition. The whole-brain functional network was constructed by thresholding functional correlation matrices of 90 brain regions (derived from the Automated Anatomic Labeling atlas). The topological properties of the brain network, including small-worldness, network efficiency, and nodal efficiency, were examined using graph theory-based analysis. Globally, the Prior-OHE group had a significantly decreased clustering coefficient and local efficiency, compared with the controls. Locally, the nodal efficiency in the bilateral medial superior frontal gyrus and the right postcentral gyrus decreased in the Prior-OHE group, while the nodal efficiency in the bilateral anterior cingulate/paracingulate gyri and rig...Continue Reading

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Citations

Oct 3, 2019·World Journal of Gastroenterology : WJG·Xiao-Yuan XuChinese Medical Association

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Software Mentioned

GRETNA
SPM
BrainNet Viewer
Automated Anatomical Labeling atlas

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