Aberrant uterine leiomyomas with extrauterine manifestation: intravenous leiomyomatosis and benign metastasizing leiomyomas

Obstetrics & Gynecology Science
Yoo-Na KimYoung Tae Kim

Abstract

Intravenous leiomyomatosis (IVL) and benign metastasizing leiomyoma (BML) are uncommon variants of benign uterine leiomyomas with extrauterine manifestations. Categorizing the extent of disease allows clinicians to delineate the clinical spectrum and the level of sophistication for complete surgical resection. Twelve patients with IVL and BML were reviewed. They were divided into early versus late stage disease groups, and initial manifestation, clinical characteristics, laboratory values, surgical pathology, and follow up data were summarized. Patients were mostly pre- or peri-menopausal and parous. Patients with late stage disease were more likely to present with cardiac symptoms or abnormal findings on chest X-ray, whereas those with early stage disease presented with classical leiomyoma symptoms including heavy menstrual bleeding, increased myoma size, or lower abdominal discomfort. Tumor marker levels were within normal ranges. A trend of higher neutrophil to leukocyte ratio was observed in the late versus the early stage group (10.4 vs. 1.51, P=0.07); the platelet leukocyte ratio was statistically higher in patients with late stage IVL (0.23 vs. 0.13, P=0.04). The overall recurrence rate was 25%. No recurrence was observe...Continue Reading

References

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Citations

Feb 2, 2019·Chinese Medical Journal·Min LiZhi-Lu Wang
Dec 5, 2018·Case Reports in Obstetrics and Gynecology·Maria Inês RaposoAlmerinda Petiz
Jul 1, 2019·Gynécologie, Obstétrique, Fertilité & Sénologie·E Declas, J P Lucot
Jul 17, 2021·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Tamar PerriJacob Korach
Aug 19, 2021·Journal of Obstetrics and Gynaecology of India·Luz Angela Torres-de la RocheRudy Leon De Wilde

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Methods Mentioned

BETA
cesarean section
hysterectomy
dissection
SMA
X-ray
surgical resections

Software Mentioned

SPSS

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