Aberrant water homeostasis detected by stable isotope analysis.

PloS One
Shannon P O'GradyJ R Ehleringer

Abstract

While isotopes are frequently used as tracers in investigations of disease physiology (i.e., 14C labeled glucose), few studies have examined the impact that disease, and disease-related alterations in metabolism, may have on stable isotope ratios at natural abundance levels. The isotopic composition of body water is heavily influenced by water metabolism and dietary patterns and may provide a platform for disease detection. By utilizing a model of streptozotocin (STZ)-induced diabetes as an index case of aberrant water homeostasis, we demonstrate that untreated diabetes mellitus results in distinct combinations, or signatures, of the hydrogen (delta2H) and oxygen (delta18O) isotope ratios in body water. Additionally, we show that the delta2H and delta18O values of body water are correlated with increased water flux, suggesting altered blood osmolality, due to hyperglycemia, as the mechanism behind this correlation. Further, we present a mathematical model describing the impact of water flux on the isotopic composition of body water and compare model predicted values with actual values. These data highlight the importance of factors such as water flux and energy expenditure on predictive models of body water and additionally pro...Continue Reading

References

May 1, 1986·The American Journal of Physiology·D A SchoellerE Jéquier
Feb 1, 1997·Journal of Applied Physiology·R J GretebeckH W Lane
Mar 20, 2001·American Journal of Respiratory and Critical Care Medicine·V Y PolotskyC P O'Donnell
Nov 6, 2003·American Journal of Physiology. Renal Physiology·Aarthi RamanFrances A Tylavsky
Feb 24, 2005·Oecologia·Gabriel J BowenKeith A Hobson
Feb 27, 2008·Proceedings of the National Academy of Sciences of the United States of America·James R EhleringerThure E Cerling
Oct 28, 2008·The Journal of Surgical Research·Michael C CheungTeresa A Zimmers
Oct 29, 2008·Science & Justice : Journal of the Forensic Science Society·Wolfram Meier-Augenstein, Isla Fraser
Feb 25, 2009·American Journal of Physical Anthropology·Gabriel J BowenThure E Cerling
Jan 29, 2010·Journal of Agricultural and Food Chemistry·Lesley A ChessonJames R Ehleringer

❮ Previous
Next ❯

Citations

Dec 15, 2010·Isotopes in Environmental and Health Studies·Shannon P O'GradyJames R Ehleringer
Sep 21, 2011·PloS One·Stephanie J PietschThomas Tütken
Sep 28, 2013·Analytica Chimica Acta·Brett J TippleJames R Ehleringer
Dec 3, 2014·Journal of Theoretical Biology·Christopher H Remien
Apr 4, 2012·Rapid Communications in Mass Spectrometry : RCM·Lesley A ChessonJames R Ehleringer
Jun 21, 2013·American Journal of Human Biology : the Official Journal of the Human Biology Council·Laurie J Reitsema
May 4, 2012·American Journal of Primatology·Shannon P O'GradyJames R Ehleringer
Jul 24, 2015·American Journal of Human Biology : the Official Journal of the Human Biology Council·Laurie J Reitsema
Jan 13, 2015·Science & Justice : Journal of the Forensic Science Society·Christine LehnMatthias Graw
Jun 8, 2018·International Journal of Legal Medicine·Christine LehnMatthias Graw
Jul 2, 2019·Isotopes in Environmental and Health Studies·Michael ZechBruno Glaser
May 29, 2015·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Irene KrukovetsOlga Stenina-Adognravi
Nov 27, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alexander BasovStepan Dzhimak

❮ Previous
Next ❯

Software Mentioned

VSMOW

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.