Aberrant White Matter Microstructure in Children and Adolescents With the Subtype of Prader-Willi Syndrome at High Risk for Psychosis

Schizophrenia Bulletin
Akvile LukosheTonya White

Abstract

Prader-Willi Syndrome (PWS) is a complex neurogenetic disorder caused by loss of the paternal 15q11.2-q13 locus, due to deletion (DEL), maternal uniparental disomy (mUPD), or imprinting center defects. Individuals with mUPD have up to 60% risk of developing psychosis in early adulthood. Given the increasing evidence for white matter abnormalities in psychotic disorders, we investigated white matter microstructure in children and adolescents with PWS, with a particular emphasis on the DEL and mUPD subtypes. Magnetic resonance diffusion weighted images were acquired in 35 directions at 3T and analyzed using fractional anisotropy (FA), mean, axial, and radial diffusivity (MD, AD, RD) values obtained by tract-based spatial statistics (TBSS) in 28 children and adolescents with PWS and 61 controls. In addition, we employed a recently developed white matter pothole approach, which does not require local FA differences to be spatially co-localized across subjects. After accounting for age and gender, individuals with PWS had significantly lower global FA and higher MD, compared with controls. Individuals with mUPD had lower FA in multiple regions including the corpus callosum, cingulate, and superior longitudinal fasciculus and larger ...Continue Reading

References

Feb 5, 1981·The New England Journal of Medicine·D H LedbetterJ D Crawford
Oct 23, 2002·Human Brain Mapping·Stephen M Smith
Jan 15, 2003·Journal of Medical Genetics·A VogelsJ-P Fryns
Oct 22, 2003·Journal of Medical Genetics·W M A VerhoevenL M G Curfs
Jan 28, 2004·Biological Psychiatry·Naama Barnea-GoralyAllan L Reiss
Nov 30, 2005·Psychiatric Genetics·Marijcke W M VeltmanPatrick F Bolton
Apr 21, 2006·NeuroImage·Stephen M SmithTimothy E J Behrens
Aug 9, 2006·Biological Psychiatry·Monte S BuchsbaumJack Gorman
Jun 30, 2007·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Andrew L AlexanderAaron S Field
Aug 1, 2008·Nature·Hreinn StefanssonKari Stefansson
Sep 23, 2008·Schizophrenia Research·Matthew J HoptmanLynn E Delisi
Mar 3, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Claudia A M Wheeler-Kingshott, Mara Cercignani
Apr 14, 2009·Topics in Magnetic Resonance Imaging : TMRI·Tonya WhiteKelvin O Lim
Nov 6, 2009·Genome Medicine·Liam S Carroll, Michael J Owen
Apr 2, 2011·Research in Developmental Disabilities·Margje SinnemaLeopold M G Curfs
Sep 23, 2011·Journal of Neuroscience Research·Rajesh KumarRonald M Harper
Apr 5, 2012·Schizophrenia Bulletin·Francesco CarlettiPhilip K McGuire
Apr 18, 2012·The Journal of Clinical Endocrinology and Metabolism·Elbrich P C SiemensmaAnita C S Hokken-Koelega
Jul 4, 2012·Archives of General Psychiatry·Patrick F SullivanPaul Lichtenstein
Sep 19, 2012·Schizophrenia Bulletin·Tonya WhiteVincent A Magnotta
Jun 6, 2013·Schizophrenia Bulletin·Christian Clemm von HohenbergMartha E Shenton
Oct 23, 2013·Journal of Neurodevelopmental Disorders·Akvile LukosheAnita C Hokken-Koelega
Nov 21, 2013·The Journal of Comparative Neurology·Matthew C JudsonBenjamin D Philpot
Dec 7, 2013·The British Journal of Psychiatry : the Journal of Mental Science·Elliott ReesGeorge Kirov
Nov 25, 2014·Cell·Maggie S Y YeungJonas Frisén
Jul 15, 2015·American Journal on Intellectual and Developmental Disabilities·Sin T LoAnita C S Hokken-Koelega

❮ Previous
Next ❯

Citations

Aug 3, 2019·Nature Communications·Nuria Domínguez-IturzaClaudia Bagni
Jan 27, 2019·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Michael D FountainChristian P Schaaf

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.