Aberrant working memory processing in major depression: evidence from multivoxel pattern classification

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Matti GärtnerSimone Grimm

Abstract

Major depressive disorder (MDD) is often accompanied by severe impairments in working memory (WM). Neuroimaging studies investigating the mechanisms underlying these impairments have produced conflicting results. It remains unclear whether MDD patients show hyper- or hypoactivity in WM-related brain regions and how potential aberrations in WM processing may contribute to the characteristic dysregulation of cognition-emotion interactions implicated in the maintenance of the disorder. In order to shed light on these questions and to overcome limitations of previous studies, we applied a multivoxel pattern classification approach to investigate brain activity in large samples of MDD patients (N = 57) and matched healthy controls (N = 61) during a WM task that incorporated positive, negative, and neutral stimuli. Results showed that patients can be distinguished from healthy controls with good classification accuracy based on functional activation patterns. ROI analyses based on the classification weight maps showed that during WM, patients had higher activity in the left DLPFC and the dorsal ACC. Furthermore, regions of the default-mode network (DMN) were less deactivated in patients. As no performance differences were observed, w...Continue Reading

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Citations

Jun 26, 2020·Psychopharmacology·Nadine WankeLars Schwabe
Mar 13, 2021·Current Behavioral Neuroscience Reports·Camilla L Nord
Mar 31, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jay C FournierMary L Phillips
Aug 4, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Diego A Pizzagalli, Angela C Roberts

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