Aberrations in peripheral inflammatory cytokine levels in substance use disorders: a meta-analysis of 74 studies.

Addiction
Ze-Xu WeiYong Cheng

Abstract

To characterize the peripheral inflammatory cytokine profile in people with substance use disorders (SUDs). Systematic review and meta-analysis. Clinical studies that evaluated peripheral blood inflammatory cytokine levels in patients with SUDs and healthy controls PARTICIPANTS: SUD patients and healthy controls. PubMed and Web of Science were systematically searched for relevant studies. Two investigators independently selected studies and extracted data. A total of 77 articles were included in the meta-analysis, containing 5649 patients with SUDs and 4643 healthy controls. Data were pooled using a random-effects model by the Comprehensive Meta-Analysis version 2 software. Concentrations of interleukin (IL)-6) in 32 studies, tumor necrosis factor (TNF)-α in 28 studies, IL-10 in 20 studies, IL-8 in 17 studies, C-reactive protein in 14 studies, IL-4 in 10 studies, IL-12 in seven studies, monocyte chemoattractant protein (MCP)-1 in 6 studies, TNF-receptor 2 (TNF-R2) in four studies and granulocyte-macrophage colony-stimulating factor (GM-CSF) in three studies were significantly higher in patients with SUDs compared with healthy controls, while concentrations of leptin in 14 studies were significantly lower in patients with SUDs c...Continue Reading

References

Dec 10, 1991·Biochimica Et Biophysica Acta·P Angel, M Karin
Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Oct 2, 1998·Movement Disorders : Official Journal of the Movement Disorder Society·S FahnT N Chase
Dec 20, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·G F Koob, M Le Moal
Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
Sep 3, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Krishnan SriramJames P O'Callaghan
Oct 9, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Vasudeva RaghavendraJoyce A DeLeo
Aug 7, 2004·BMC Medical Research Methodology·Carl V Phillips
Sep 3, 2004·Journal of Neuroimmunology·Shannon M ConroyDonna L Gruol
Jul 22, 2005·Nature Reviews. Immunology·Stuart M AllanNancy J Rothwell
Oct 28, 2005·Nature Neuroscience·Eric J Nestler
Jan 15, 2008·Experimental Neurology·Jun He, Fulton T Crews
Feb 26, 2008·European Journal of Pharmacology·Renato Malcher-LopesJeffrey G Tasker
May 15, 2008·Journal of Epidemiology and Community Health·R HerringB Thom
Oct 22, 2008·Brain, Behavior, and Immunity·Mark R HutchinsonKirk W Johnson
Apr 8, 2009·Cell and Tissue Research·J B Dietrich
Jul 28, 2009·Journal of Clinical Epidemiology·David MoherUNKNOWN PRISMA Group
Dec 18, 2009·Biological Psychiatry·Yekta DowlatiKrista L Lanctôt
Aug 10, 2010·Biological Psychiatry·Walter SwardfagerNathan Herrmann
Apr 7, 2011·Current Drug Abuse Reviews·Ruth Janke van Holst, Thelma Schilt
Jun 7, 2011·Biological Psychiatry·Brian J MillerBrian Kirkpatrick
Jun 20, 2012·Journal of Neuroinflammation·Liya Qin, Fulton T Crews
Jul 4, 2012·Frontiers in Pharmacology·Sharanya M KousikPaul M Carvey
Sep 19, 2012·Neuroscience Letters·Seong Shoon YoonChae Ha Yang
Jan 12, 2013·Science·Ira Tabas, Christopher K Glass
Oct 1, 2013·Neuroscience Letters·Seong Shoon YoonChae Ha Yang
Nov 13, 2013·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·María PascualConsuelo Guerri
Mar 25, 2015·British Journal of Pharmacology·Ruben OrihuelaGaylia Jean Harry
Apr 22, 2015·Nature Reviews. Neuroscience·Michael V Sofroniew
Sep 4, 2015·Research Synthesis Methods·Areti Angeliki VeronikiGeorgia Salanti
Sep 26, 2015·Pharmacological Reviews·Esa R KorpiGavin S Dawe
Feb 4, 2016·The American Journal of Drug and Alcohol Abuse·Jessica L MontoyaUNKNOWN Translational Methamphetamine Aids Research Center (TMARC) Group
Feb 14, 2016·Psychopharmacology·Irina N KrasnovaJean Lud Cadet
Dec 6, 2016·Cytokine·Antonio La Cava
Feb 6, 2017·Neuropharmacology·Fulton T CrewsLeon G Coleman

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Citations

Feb 26, 2021·Drug and Alcohol Dependence·April C MayUNKNOWN T1000 Investigators
Apr 17, 2021·Neuropharmacology·Katherine M SerafineEric P Zorrilla

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