Abeta-2M-amyloidosis and related bone diseases

Journal of Bone and Mineral Metabolism
J J KazamaF Gejyo

Abstract

Abeta-2M-amyloidosis is a type of systemic amyloidosis that is specifically seen in patients with chronic kidney diseases. The precursor protein of Abeta-2M-amyloid fibril is beta2-microglobulin, and its elevated serum level is the main cause of Abeta-2M-amyloidosis in patients with kidney failure. However, the precise mechanism of Abeta-2M-amyloidogenesis remains unclear. In vitro analyses of Abeta-2M amyloidogenesis are still being actively conducted. Osteolytic lesions are often found around synovial membrane with Abeta-2M-amyloid deposition. Both evident osteoclastogenesis and active osteoclastic bone resorption are found, while osteoblastic bone formation is absent in the lesion most likely associated with the inflammation caused by infiltrating macrophages/monocytes into Abeta-2M-amyloid deposition. The precise cell biological mechanism of this inflammatory change is unknown. Further studies are needed to establish specific treatments against this as yet unsolved problem with long-term dialysis therapy.

References

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Citations

Jan 8, 2013·Journal of Bone and Mineral Metabolism·Minako WakasugiIchiei Narita
Jan 11, 2011·The Journal of Biological Chemistry·Daisaku OzawaHironobu Naiki
Jul 16, 2014·Kidney International Supplements·Junichiro J KazamaMasafumi Fukagawa
Mar 28, 2008·Kidney International·C MenaaS M Sprague
Apr 12, 2014·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Minako WakasugiIchiei Narita
Feb 6, 2015·Journal of Bone and Mineral Metabolism·Junichiro James KazamaMasafumi Fukagawa
Sep 16, 2008·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Erkan DervisogluAhmet Yilmaz
Feb 6, 2013·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Fumitake GejyoUNKNOWN Society of β2-Microglobulin Adsorption Therapy
Jul 20, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chundong HuangLingyun Jia
Jun 6, 2013·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Masafumi FukagawaUNKNOWN Japanese Society for Dialysis Therapy

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