Abeta-peptide length and apolipoprotein E genotype in Alzheimer's disease

Annals of Neurology
M GearingS S Mirra

Abstract

Apolipoprotein E (ApoE) epsilon4 allele, a risk factor for the development of Alzheimer's disease (AD), is associated with increased amyloid deposition. We examined cerebral cortex in 68 AD cases using antibodies to beta-amyloid (Abeta) peptides of different length (Abeta1-40 and Abeta1-42) and found that the increased plaque frequency observed with epsilon4 genotypes may be largely attributed to an increase in Abeta1-40-positive plaques. Indeed, both the number of Abeta1-40-positive plaques, as well as the ratio of Abeta1-40/Abeta1-42-positive plaques, increased with epsilon4 dosage. In contrast, the frequency of Abeta1-42-immunoreactive plaques was similar for epsilon3/epsilon3, epsilon3/epsilon4, and epsilon4/epsilon4 genotypes. ApoE may influence Abeta1 length by facilitating Abeta1-40 deposition onto Abeta1-42-seeded plaques or by modulating the activity of a putative carboxypeptidase that forms Abeta1-40 from Abeta1-42 in situ.

References

Jun 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·J E MaggioP W Mantyh
Nov 1, 1995·Journal of Neuropathology and Experimental Neurology·M GearingS S Mirra
Mar 1, 1995·Annals of Neurology·S G Younkin
Apr 21, 1995·The Journal of Biological Chemistry·M J LaDuM T Falduto
Sep 1, 1994·Journal of Neuropathology and Experimental Neurology·D J Selkoe
Sep 18, 1993·Lancet·J PoirierS Gauthier
Sep 24, 1993·Annals of the New York Academy of Sciences·J T JarrettP T Lansbury
Oct 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·D E SchmechelA D Roses
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·W J StrittmatterA D Roses

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Citations

Jul 16, 2008·Archives of Neurology·Joshua R SteinermanYaakov Stern
Nov 17, 2011·Journal of Neural Transmission·Nady BraidyGilles J Guillemin
May 1, 1997·Journal of the Neurological Sciences·A TamaokaH Mori
Nov 25, 1997·Brain Research. Brain Research Reviews·L C Walker
Jun 12, 1998·Brain Research. Brain Research Reviews·U BeffertJ Poirier
Oct 28, 1999·Neurobiology of Aging·S Y Guénette, R E Tanzi
Oct 29, 2002·Neuroscience Letters·Kazuhiro IshiiHiroshi Mori
Jun 26, 2003·The International Journal of Biochemistry & Cell Biology·Yan LingNoor Kalsheker
Aug 1, 1997·Current Opinion in Chemical Biology·P T Lansbury
Apr 2, 2005·Nature Reviews. Neuroscience·Til MengeOlaf Stüve
Oct 9, 2009·Alzheimer Disease and Associated Disorders·Xiaoyan SunWei Qiao Qiu
Dec 16, 1996·Annals of the New York Academy of Sciences·Y J KwonN R Relkin
Aug 19, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·D A BennettS E Arnold
Dec 28, 1999·Proceedings of the National Academy of Sciences of the United States of America·K R BalesS M Paul
Oct 19, 2002·Nutritional Neuroscience·A V Rao, B Balachandran
Dec 15, 2016·Expert Opinion on Drug Discovery·Debby Van Dam, Peter Paul De Deyn
Aug 15, 2009·Neuron·Jungsu KimDavid M Holtzman
Aug 11, 2000·Microscopy Research and Technique·L BaumC P Pang
Aug 11, 2000·Microscopy Research and Technique·G M Cole, M D Ard
Oct 19, 2000·Neuropathology : Official Journal of the Japanese Society of Neuropathology·H Mori
Jul 18, 2002·The Journal of Biological Chemistry·Woj M WojtowiczTajib Mirzabekov

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