Abeta production as consequence of cellular death of a human neuroblastoma overexpressing APP

FEBS Letters
María RecueroFernando Valdivieso

Abstract

In human brain the Abeta peptide is produced mainly by neurons and the overexpression of amyloid precursor protein (APP) that involves an increase in Abeta secretion, has been observed in some areas of the Alzheimer's disease patients brain. We have generated two stably transfected human neuroblastoma lines which overexpress APP; both of them secreted Abeta and showed morphological changes and cell death with apoptotic program characteristics. Interestingly, coculture experiments with the untransfected human neuroblastoma cell line showed that the Abeta peptide was not responsible for the death in those cell lines; additionally, we indicate that upon cell death, Abeta peptide is secreted into cell medium.

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Citations

Dec 28, 2007·Mechanisms of Ageing and Development·Tiziana CasoliCarlo Bertoni-Freddari
Nov 6, 2007·Neuroscience Letters·Matthew A WozniakCurtis B Dobson
Aug 25, 2015·Therapeutic Advances in Drug Safety·Florindo StellaOrestes V Forlenza
Oct 23, 2010·FEBS Letters·María RecueroFernando Valdivieso
Apr 23, 2020·Journal of Neurochemistry·Igor C FontanaEduardo R Zimmer
Jun 3, 2021·Cells·Jesús BurilloCarlos Guillén
May 5, 2006·Neurobiology of Aging·Pamela R WestmarkJames S Malter
Nov 23, 2006·Biochimica Et Biophysica Acta·Ekaterini CopanakiDonat Kögel
May 18, 2010·Molecular and Cellular Neurosciences·Ekaterini CopanakiThomas Deller

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