Abeta/Cu-catalyzed oxidation of cholesterol in 1,2-dipalmitoyl phosphatidylcholine liposome membrane

Journal of Bioscience and Bioengineering
Toshinori ShimanouchiRyoichi Kuboi

Abstract

The amyloid beta protein with 42 amino acid residues (Abeta), which is a causative protein of Alzheimer's disease (AD), forms the complex with copper (II) to induce the cholesterol oxidase-like activity by the proton transfer from the cholesterol. In this study, the oxidation of cholesterol by Abeta/Cu complex was investigated on the surface of the zwitterionic phospholipid liposome including the bound water advantageous for the enhancement of the proton transfer. The bound water was pooled by the formation of cholesterol-rich domain within liposomes. The resulting reactivity was enhanced by the proton transfer mediated by the bound water.

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Citations

Jul 26, 2011·Nucleic Acids Research·Keishi SugaHiroshi Umakoshi
Sep 16, 2011·Journal of Bioscience and Bioengineering·Toshinori ShimanouchiRyoichi Kuboi
Apr 20, 2010·Biotechnology Journal·Keishi SugaRyoichi Kuboi

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