Abetimus sodium (riquent) for the prevention of nephritic flares in patients with systemic lupus erythematosus

Rheumatic Diseases Clinics of North America
Richard Furie

Abstract

Abetimus sodium has been under development for the treatment of systemic lupus erythematosus since the early 1990s. Because its administration results in the selective reduction of circulating double-stranded DNA antibodies, La Jolla Pharmaceutical Company has focused on the agent's ability to prolong time to nephritic flare. Fourteen trials have been initiated since 1994, but the two pivotal registration trials failed to meet primary end points. The US Food and Drug Administration issued a letter in October 2004 that stated abetimus sodium was "approvable" pending the successful completion of a trial demonstrating clinical benefit. The fate of this agent lies in the ability of the company to successfully complete a phase III study.

References

Apr 1, 1996·Lupus·S M CouttsC M Berner

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Citations

Aug 27, 2009·Biologics : Targets & Therapy·Mary H Foster
Jan 22, 2008·Expert Reviews in Molecular Medicine·Meera Ramanujam, Anne Davidson
Nov 28, 2012·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Marilynn G Punaro
Jun 10, 2009·Expert Opinion on Pharmacotherapy·Diane M Horowitz, Richard A Furie
May 14, 2011·Autoimmunity Reviews·Guillermo J Pons-EstelRicard Cervera
Mar 31, 2009·Journal of Autoimmunity·Robert Eisenberg
Jul 1, 2008·Reumatología clinica·Lucía Silva FernándezEllen M Ginzler
Dec 11, 2007·Best Practice & Research. Clinical Rheumatology·Jennifer K King, Bevra H Hahn
Jul 13, 2007·Current Opinion in Pharmacology·Gregg J Silverman, Sahil Khanna
May 21, 2008·Lupus·F A Houssiau, E M Ginzler
Nov 15, 2006·Drugs·Ramin Sabahi, Jennifer H Anolik

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