ABH and Lewis antigen distributions in blood, saliva and gastric mucosa and H pylori infection in gastric ulcer patients

World Journal of Gastroenterology : WJG
Luisa Caricio MartinsJuciclayton Tavares de Souza

Abstract

To investigate the ABH and Lewis antigen expression in erythrocytes, saliva and gastric epithelium, as well as the association between H pylori and the presence of gastric epithelial lesions. The distribution of ABH and Lewis blood group antigens in erythrocytes, saliva and gastric mucosa of H pylori-infected gastric ulcer patients was analyzed. Forty-two patients with gastric ulcer were studied, and fifty healthy individuals were used as control group. The blood group antigens were determined by direct hemagglutination, dot-ELISA and immunohistochemical methods in erythrocytes, saliva and gastric mucosa specimens, respectively. Diagnosis for H pylori infection was performed by conventional optical microscopy and ELISA. A higher seroprevalence of IgG H pylori specific antibodies was observed in gastric ulcer patients (90%) compared to the control group (60%). We observed a significant increase of phenotypes O, A2 and Lewis b in H pylori-infected patients. The expression of these antigens had progressive alterations in areas of ulcerous lesions and intestinal metaplasia. ABH and Lewis blood group antigens are a good indicator for cellular alterations in the gastric epithelium.

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Citations

Aug 22, 2008·Digestive Diseases and Sciences·Kadim BayanFikri Canoruc
Jun 19, 2015·Clinical Microbiology Reviews·Laura Cooling
Mar 17, 2018·Glycobiology·Oliver M T Pearce
Jan 5, 2012·PLoS Neglected Tropical Diseases·Mohammad ArifuzzamanFirdausi Qadri
Jun 21, 2014·International Journal of Cancer. Journal International Du Cancer·Eric J DuellCarlos A González
May 10, 2019·Vox Sanguinis·Christopher P Stowell, Sean R Stowell
Mar 2, 2021·Frontiers in Cellular and Infection Microbiology·Margarita Camorlinga-PonceJavier Torres
Jul 6, 2021·Frontiers in Cellular and Infection Microbiology·Luiz Carlos De MattosCinara Cássia Brandão
Jun 29, 2021·Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur̈ Transfusionsmedizin Und Immunham̈atologie·Didar Yanardag Acik, Mehmet Bankir

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