Abilities of activated macrophages to manifest tumoricidal activity and to generate reactive nitrogen intermediates: a comparative study in vitro and ex vivo

Biochemical and Biophysical Research Communications
R Keller, R Keist

Abstract

The abilities of lymphokines and heat-killed bacteria to induce and to maintain tumoricidal activity and/or the secretion of reactive nitrogen intermediates (RNI) were comparatively assessed in bone marrow-derived mononuclear phagocytes (BMM phi) in vitro and in adherent peritoneal cells (APC) ex vivo. In showing that the kinetics of tumoricidal activity and of secretion of RNI induced by macrophage-activating agents in BMM phi and/or in peritoneal cells do largely parallel each other, the present findings provide evidence for a role of RNI in tumor cell killing by activated macrophages both in vitro and in vivo.

References

Apr 1, 1989·European Journal of Cancer & Clinical Oncology·R Keller
Apr 15, 1989·Cellular Immunology·R KellerR Keist
Sep 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·R IyengarM A Marletta
Nov 30, 1988·Biochemical and Biophysical Research Communications·J B HibbsE M Rachlin
Jan 1, 1984·Annual Review of Immunology·D O Adams, T A Hamilton

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Citations

Aug 1, 1993·International Journal of Immunopharmacology·S S LefkowitzD L Lefkowitz
Jul 20, 1999·International Journal of Immunopharmacology·E Y MoonS Pyo
Feb 24, 2000·International Journal of Immunopharmacology·E Y Moon, S Pyo
May 18, 2005·The Journal of Antibiotics·Hiroyuki KumagaiDaishiro Ikeda
Jan 29, 2000·Immunology and Cell Biology·F A WallaceP C Calder
Apr 20, 1999·The Journal of Experimental Medicine·T S GriffithN A Fanger
Jan 1, 1993·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·W K LiuC C Wong
May 1, 1993·Research in Immunology·J Klostergaard
Mar 10, 2012·Toxicon : Official Journal of the International Society on Toxinology·G BiancoL Severino
Oct 15, 1990·International Journal of Cancer. Journal International Du Cancer·R KellerP H van der Meide

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