Abstract
Orthopedic metal implants are notoriously associated with release of metallic ions able to cause biological adverse reactions which might lead to implant loosening and failure. To limit any possible adverse reactions, ceramic coatings for orthopedic metal implants have been introduced. However, information regarding the interaction of these coatings with microbes responsible for periprosthetic joint infections (PJIs) is lacking. Hence, the aim of the present in vitro study is to assess the microbial affinity to a titanium-niobium nitride (TiNbN) coating. Adhesion and biofilm formation of clinical isolates of Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa, and Cutibacterium acnes were assessed on TiNbN-coated titanium discs in comparison with uncoated titanium and cobalt-chrome alloys discs, with either smooth or rough surfaces. Bacterial adhesion was performed by counting adhered bacteria in the first hours of incubation, and the biofilm formation was performed by means of a spectrophotometric assay and by confocal laser scan microscopy after 72 hours of incubation. Overall, Staphylococcus aureus and Staphylococcus epidermidis, among the most common bacteria responsible for PJIs, displayed a significa...Continue Reading
References
Dec 1, 1985·Journal of Clinical Microbiology·G D ChristensenE H Beachey
Dec 12, 2001·Clinical Oral Implants Research·B Grössner-SchreiberU B Göbel
May 23, 2003·The Journal of Oral Implantology·Antonio ScaranoAdriano Piattelli
Sep 24, 2010·Acta Orthopaedica·Anton H HosmanDanielle Neut
Aug 23, 2011·Journal of Dentistry·Marco AnnunziataLuigi Guida
Jan 15, 2014·The Journal of Knee Surgery·Vinay K AggarwalDaniel Kendoff
Sep 1, 2015·Archives of Orthopaedic and Trauma Surgery·Emmanuel Thienpont
Nov 4, 2015·International Orthopaedics·Daniel GuentherCarl Haasper
Nov 6, 2015·Implant Dentistry·Neslin VeliogluAhmet Ozkomur
Nov 20, 2015·BioMed Research International·Ruud P van HovePeter A Nolte
Jan 12, 2016·The Journal of the American Academy of Orthopaedic Surgeons·Paul F LachiewiczJoshua J Jacobs
Jul 6, 2016·Clinical Orthopaedics and Related Research·Sumon Nandi
Nov 22, 2016·Critical Reviews in Microbiology·Joana AzeredoClaus Sternberg
Feb 9, 2017·HSS Journal : the Musculoskeletal Journal of Hospital for Special Surgery·Martin FaschingbauerFriedrich Boettner
Apr 10, 2017·The Journal of Arthroplasty·Lorenzo DragoLaura Cappelletti
Apr 14, 2017·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Werner Zimmerli, Parham Sendi
Aug 2, 2017·PloS One·Alessandro BidossiLorenzo Drago
Jun 27, 2018·PloS One·Giulia BrunelloStefano Sivolella
Jul 6, 2019·Biomedical Microdevices·Vincenza RagoneEmanuela Galliera
Citations
Dec 18, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Andrea LucaAlessandro Bidossi
Oct 17, 2020·Medical Devices : Evidence and Research·Annette KienleHans-Joachim Wilke
Dec 10, 2020·International Journal of Molecular Sciences·Alessandro BidossiElena De Vecchi
Nov 12, 2021·ACS Infectious Diseases·Erika L CyphertHorst A von Recum