Ability of adhesion and biofilm formation of pathogens of periprosthetic joint infections on titanium-niobium nitride (TiNbN) ceramic coatings

Journal of Orthopaedic Surgery and Research
Alessandro BidossiElena De Vecchi

Abstract

Orthopedic metal implants are notoriously associated with release of metallic ions able to cause biological adverse reactions which might lead to implant loosening and failure. To limit any possible adverse reactions, ceramic coatings for orthopedic metal implants have been introduced. However, information regarding the interaction of these coatings with microbes responsible for periprosthetic joint infections (PJIs) is lacking. Hence, the aim of the present in vitro study is to assess the microbial affinity to a titanium-niobium nitride (TiNbN) coating. Adhesion and biofilm formation of clinical isolates of Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa, and Cutibacterium acnes were assessed on TiNbN-coated titanium discs in comparison with uncoated titanium and cobalt-chrome alloys discs, with either smooth or rough surfaces. Bacterial adhesion was performed by counting adhered bacteria in the first hours of incubation, and the biofilm formation was performed by means of a spectrophotometric assay and by confocal laser scan microscopy after 72 hours of incubation. Overall, Staphylococcus aureus and Staphylococcus epidermidis, among the most common bacteria responsible for PJIs, displayed a significa...Continue Reading

References

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Citations

Dec 18, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Andrea LucaAlessandro Bidossi
Oct 17, 2020·Medical Devices : Evidence and Research·Annette KienleHans-Joachim Wilke

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Methods Mentioned

BETA
laser scan microscopy
total hip arthroplasty

Software Mentioned

Image J
GraphPad Prism
Fiji
Las X

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