PMID: 16538297Mar 16, 2006Paper

Ability of moisturizers to reduce dry skin and irritation and to prevent their return

Journal of Cosmetic Science
F A SimionZoe Diana Draelos

Abstract

Assays of moisturizer efficacy have traditionally focused on a moisturizer's ability to alleviate dry skin. More recently, a moisturizer's ability to prevent primary irritation has been recognized. To assess and compare the ability of moisturizers to alleviate skin dryness and primary irritation, as well as prevent their return, four controlled-application clinical (in vivo) studies were carried out: hand-wash test, regression test, reduction in pre-existing irritation study, and prevention-of-irritation studies. Overall conclusions were confirmed in a home-use clinical (validation) study of people suffering from mild eczema. The controlled in vivo studies demonstrate that: (a) a moisturizer can alleviate skin dryness and irritation, and prevent their return; and (b) the efficacy of different moisturizers can be differentiated, based on their composition. The home-use study results demonstrated that the most effective moisturizer identified by the controlled-application studies was highly effective against the signs of eczema. In vivo modeling of moisturizer efficacy enables assessment and optimization of different benefits separately, while predicting the quantitative and perceived (observed) relevance of the benefits the mois...Continue Reading

Citations

Sep 26, 2013·Toxicology in Vitro : an International Journal Published in Association with BIBRA·D M CameronF A Simion
Aug 26, 2006·Contact Dermatitis·Miki Yokota, Howard I Maibach
Nov 28, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wojciech KochWirginia Kukula-Koch

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