Ability of mononuclear phagocytes from cattle naturally resistant or susceptible to brucellosis to control in vitro intracellular survival of Brucella abortus.

Infection and Immunity
R E PriceL G Adams

Abstract

The role of bovine mammary macrophages and peripheral blood monocyte-derived macrophages in natural resistance to bovine brucellosis was evaluated. A group of 11 naturally resistant and 10 chronically infected susceptible cows was studied following challenge with Brucella abortus. Macrophages from a greater proportion (P less than 0.026) of naturally resistant cows were significantly superior to macrophages from susceptible cows in their ability to inhibit the in vitro intracellular replication of B. abortus after challenge exposure. Studies of a second group of cows used mammary macrophages from 12 heifers and blood monocyte-derived macrophages from 22 bulls and heifers. These tests were completed before exposure to B. abortus, using mammary macrophages (P less than 0.039) and blood monocyte-derived macrophages (P less than 0.045), and also showed that macrophages from naturally resistant cattle were significantly superior in their ability to control the in vitro intracellular replication of B. abortus. Our data indicate that the mononuclear phagocytes from more than 80% of the resistant cattle controlled intracellular replication of B. abortus significantly better than did mononuclear phagocytes from susceptible cattle. Monon...Continue Reading

References

Dec 1, 1979·New Zealand Veterinary Journal·D O Cordes, M E Carter
Sep 1, 1985·Somatic Cell and Molecular Genetics·H F WillardM L Breitman
Aug 1, 1987·Australian Veterinary Journal·L A CornerH Iyer
Dec 1, 1986·Veterinary Immunology and Immunopathology·H Bielefeldt Ohmann, L A Babiuk
Aug 1, 1985·Veterinary Immunology and Immunopathology·C L BaldwinA J Winter
Aug 1, 1983·Journal of Dairy Science·S P Targowski
Sep 1, 1983·Reviews of Infectious Diseases·E Skamene
Mar 1, 1984·Infection and Immunity·P R CrockerD J Bradley
Jan 1, 1980·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·C García-Carrillo
Jul 1, 1982·Proceedings of the Society for Experimental Biology and Medicine·D M ReinitzI H Mather

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Citations

Sep 24, 2005·Infection and Immunity·Sonja BurkhardtStephan Köhler
Aug 23, 2008·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·R MartinezJ Cañón
May 22, 2013·PloS One·Hugo Esquivel-SolísJosé A Gutiérrez-Pabello
Aug 10, 2000·Clinical and Experimental Immunology·J SathiyaseelanC L Baldwin
Mar 23, 2006·Infection and Immunity·Giorgia BorrielloDomenico Iannelli
Jan 1, 1992·Scandinavian Journal of Immunology. Supplement·P S Gwakisa, U M Minga
Jan 24, 2003·Infection and Immunity·Laurence A GuilloteauDominique Kerboeuf
Mar 6, 2007·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Rosanna CapparelliDomenico Iannelli
Mar 21, 2009·Journal of Applied Microbiology·R CapparelliD Iannelli
Apr 23, 2004·Molecular Microbiology·R Martin RoopJames A Cardelli
Nov 18, 2020·Pathogens·Magalí G BialerAngeles Zorreguieta
Jan 1, 1991·Clinical Microbiology Reviews·J F Prescott
Oct 1, 1996·Genome Research·J FengJ W Templeton

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