Ability of polyvinylpyrrolidone and polyacrylic acid to inhibit the crystallization of amorphous acetaminophen

Journal of Pharmaceutical Sciences
Tamaki MiyazakiShigeo Kojima

Abstract

The inhibition of crystallization of amorphous acetaminophen (ACTA) by polyvinylpyrrolidone (PVP) and polyacrylic acid (PAA) was studied using amorphous solid dispersions prepared by melt quenching. Co-melting with PVP and PAA decreased the average molecular mobility, as indicated by increases in glass transition temperature and enthalpy relaxation time. The ACTA/PAA dispersion exhibited much slower crystallization than the ACTA/PVP dispersion with a similar glass transition temperature value, indicating that interaction between ACTA and polymers also contributed to the stabilizing effect of these polymers. The carboxyl group of PAA may interact with the hydroxyl group of ACTA more intensely than the carbonyl group of PVP does, resulting in the stronger stabilizing effect of PAA. Dielectric relaxation spectroscopy showed that the number of water molecules tightly binding to PVP per monomer unit was larger than that to PAA. Furthermore, a small amount of absorbed water decreased the stabilizing effect of PVP, but not that of PAA. These findings suggest that the stronger stabilizing effect of PAA is due to the stronger interaction with ACTA. The ability of PAA to decrease the molecular mobility of solid dispersion was also larger...Continue Reading

References

Jul 5, 1990·Biopolymers·N ShinyashikiN Sasaki
Aug 26, 2000·Chemical & Pharmaceutical Bulletin·P di MartinoS Martelli
Sep 13, 2002·Journal of Pharmaceutical Sciences·Kieran J Crowley, George Zografi

❮ Previous
Next ❯

Citations

Aug 24, 2006·Pharmaceutical Research·Patrick J MarsacLynne S Taylor
Aug 26, 2006·Pharmaceutical Research·Patrick J MarsacLynne S Taylor
Sep 23, 2009·Pharmaceutical Research·Alfred C F RumondorLynne S Taylor
Apr 15, 2008·Archives of Pharmacal Research·Muhammad Tayyab Ansari, Vivian Bruce Sunderland
Apr 27, 2012·Molecular Pharmaceutics·Ritu MalikAmit Misra
Aug 2, 2006·Chemical & Pharmaceutical Bulletin·Tamaki MiyazakiYukio Aso
Jan 6, 2009·Chemical & Pharmaceutical Bulletin·Yukio AsoToru Kawanishi
May 17, 2014·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Andrew V EwingSergei G Kazarian
Mar 17, 2015·Drug Development and Industrial Pharmacy·Srinivasan ShanmugamJong Soo Woo
Aug 16, 2006·Drug Development and Industrial Pharmacy·M A El-MassikN A Daabis
Aug 31, 2007·Drug Development and Industrial Pharmacy·Subrata MallickPintu K De
Aug 8, 2006·Journal of Pharmaceutical Sciences·Hajime Konno, Lynne S Taylor
Jan 4, 2012·Journal of Pharmaceutical Sciences·Blair BrettmannBernhardt Trout
Mar 14, 2012·Journal of Pharmaceutical Sciences·Blair Kathryn BrettmannBernhardt L Trout
Apr 27, 2011·Journal of Pharmaceutical Sciences·Jenifer MacleanKarthik Nagapudi
Apr 25, 2007·Journal of Pharmaceutical Sciences·Jaidev S TantryRaj Suryanarayanan
Aug 28, 2007·Journal of Pharmaceutical Sciences·Chandan Bhugra, Michael J Pikal
Apr 24, 2015·Journal of Pharmaceutical Sciences·Maxx Capece, Rajesh Davé
Feb 9, 2016·Pharmaceutical Development and Technology·Ashwini Kini, Sarsvatkumar B Patel
Nov 28, 2012·International Journal of Pharmaceutics·Sejal ShahMichael A Repka
Aug 17, 2011·Advanced Drug Delivery Reviews·Jared A Baird, Lynne S Taylor
Feb 1, 2011·International Journal of Pharmaceutics·Tamaki MiyazakiToru Kawanishi
Jun 26, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Hajime KonnoLynne S Taylor
Dec 23, 2006·International Journal of Pharmaceutics·Tamaki MiyazakiToru Kawanishi
Apr 9, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Min Yang, Costas Gogos
May 21, 2013·Pharmaceutical Development and Technology·Yusuke ShibataYoshiteru Watanabe
May 18, 2016·Journal of Pharmaceutical Sciences·Donghua Alan ZhuGeoff G Z Zhang
Jun 9, 2016·Expert Opinion on Drug Delivery·Tu Van Duong, Guy Van den Mooter

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.