PMID: 2494440Apr 1, 1989Paper

Ability of structurally related polycyclic aromatic carcinogens to induce homologous recombination between duplicated chromosomal sequences in mouse L cells

Mutation Research
N P BhattacharyyaJ J McCormick

Abstract

To investigate the role of DNA damage in the induction of homologous recombination in mammalian cells, a series of structurally related, polycyclic aromatic carcinogens, i.e., 1-nitrosopyrene (1-NOP), N-acetoxy-2-acetylaminofluorene (N-AcO-AAF), and 4-nitroquinoline 1-oxide (4-NQO), were compared for their ability to cause intrachromosomal homologous recombination between two herpes simplex virus thymidine kinase (Htk) genes stably integrated in the genome of a tk- mouse L cell strain 333 M. Each Htk gene contains an 8-bp XhoI linker inserted at a unique site so that expression of a functional Htk enzyme requires a productive recombinational event between the two nonfunctional genes. Each carcinogen caused a dose-dependent increase in the frequency of recombination. The results were compared to what had been found previously for a structurally related carcinogen, (+/-)-7 beta, 8 alpha-dihydroxy-9 alpha, 10 alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE). As a function of concentration, BPDE was the most active agent, followed by 4-NQO, and 1-NOP, and then N-AcO-AAF. When compared on the basis of equal cell killing, the most efficient carcinogen was 1-NOP, followed by N-AcO-AAF and BPDE, and then 4-NQO. Use of tritium-label...Continue Reading

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Citations

Dec 1, 1992·Mutation Research·D Hellgren
Jul 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·Z LuoP M Glazer
Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·T TsujimuraJ J McCormick
Jan 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·E G LebelJ Paszkowski
Jan 11, 2005·Médecine sciences : M/S·Yannick SaintignyBernard S Lopez
Jan 1, 1994·Critical Reviews in Toxicology·C Sengstag

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