Abstract
Sensitivity to the bitter compound 6-n-propylthiouracil (PROP) is genetically mediated. Sensitivity to PROP has been associated with weight status in both adults and children. To determine whether there is an association between PROP sensitivity and BMI in low-income children of diverse race/ethnicity, among whom there is a high prevalence of obesity. Eighty-one preschool-aged children attending Head Start tasted a solution of 560 micromol/l PROP and reported whether it tasted "like water" or "like something else". Mothers reported child's race, age, maternal education, maternal weight and height, child's reluctance to sample new foods via the Food Neophobia Scale (FNS), and child's dietary intake using a food frequency questionnaire. Child weight and height were measured. BMI was calculated and for children, expressed in z-scores. Regression analyses were used to evaluate the relationship between child's PROP taster status and BMI z-score, testing covariates child's age, gender, race, maternal education and BMI, and child's FNS score. Children's dietary intake was compared by PROP taster status. PROP tasters, compared with nontasters, had significantly higher BMI z-scores (0.99 (s.d. 1.24) vs. 0.03 (1.12), P=0.004) and had a s...Continue Reading
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