PMID: 15224736Jul 1, 2004Paper

Abiotic transformation of toxaphene by superreduced vitamin B12 and dicyanocobinamide

Environmental Science & Technology
Steffen RuppeWalter Vetter

Abstract

Toxaphene is a complex organochlorine pesticide mixture, residues of which are widespread in the environment. Previous studies with the isolated bacterium Sulfurospirillum (formerly Dehalospirillum) multivorans resulted in an effective anaerobic biotransformation of toxaphene. Since the bacterium contains a corrinoid derivative in the active center of the tetrachloroethene dehalogenase, we attempted to use superreduced corrinoids for abiotic transformation of toxaphene. The two corrinoids studied were dicyanocobinamide and cyanocobalamin (vitamin B12). Superreduced dicyanocobinamide mediated a rapid transformation of toxaphene. More than 90% of the initial pool was transformed within 6 h. The transformation was nonselective, and even the most persistent metabolite in environmental samples, the so-called dead-end metabolite 2-exo,3-endo,6-exo,8,9,10-hexachlorobornane (B6-923 or Hx-Sed) was transformed within hours. Superreduced cyanocobalamin was also able to transform toxaphene albeit at significantly lower velocity. The lack of transformation products detectable in gas chromatograms of hexanes-extracted fractions of the assays suggests rapid, sequential dehalogenation and/or destruction of the C10-hydrocarbon backbone of the c...Continue Reading

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Citations

Aug 7, 2008·Dalton Transactions : an International Journal of Inorganic Chemistry·Sarah Kliegman, Kristopher McNeill
Nov 4, 2009·Dalton Transactions : an International Journal of Inorganic Chemistry·Ling PanYoshio Hisaeda
Jan 1, 2017·ChemPlusChem·Hisashi Shimakoshi, Yoshio Hisaeda
Nov 22, 2005·Environmental Science & Technology·Joachim MelcherWalter Vetter
Jun 3, 2021·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Hisashi Shimakoshi, Yoshio Hisaeda
Jul 13, 2006·Journal of the American Chemical Society·Mathew D Liptak, Thomas C Brunold

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