Abl expression in human fetal and adult tissues, tumours, and tumour microvessels

The Journal of Pathology
A J O'NeillE F Gaffney

Abstract

Abl kinases encoded by the abl oncogenes inhibit apoptosis without affecting cell proliferation. The aim of this study was to examine a wide range of normal fetal and adult human tissues and a variety of tumour types for Abl immunoreactivity. Sections from 193 paraffin blocks of normal fetal and adult tissues and 72 blocks from representative tumours were stained immunohistochemically using a polyclonal antibody to c-Abl/Bcr-Abl oncoprotein. Weak Abl immunoreactivity was observed in many adult tissues. Moderately intense or strong staining (cytoplasmic, nuclear or membranous) was consistently seen in hyaline cartilage, adipocytes, and ciliated epithelium. In fetal tissues, there was a broadly similar staining pattern, but Abl expression was also seen in muscle (all types) and occasionally in endothelial cells. The most intense staining was seen in sites of endochondral ossification and in the umbilical cord stroma. Negatively staining tissues included epidermis and squamous mucosa, lymph nodes, tonsil, spleen, hepatocytes, and adrenals. Most tumours showed focal or weak Abl immunoreactivity. The most intense staining was seen in chondrosarcoma, liposarcoma, and diffuse gastric (signet ring) adenocarcinoma. In the latter two tum...Continue Reading

References

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Citations

Nov 5, 2014·Proceedings of the National Academy of Sciences of the United States of America·Rom KeshetYosef Shaul
Apr 5, 2000·Molecular Pathology : MP·M O'DonovanE F Gaffney
Nov 8, 2011·The Journal of Biological Chemistry·Miriam CantoreDieter Häussinger
Dec 15, 2000·Oncogene·W LinH C Chen
Mar 7, 2020·Journal of Receptor and Signal Transduction Research·Aylin YabaBayram Yılmaz
Nov 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jing Jin GuAnn Marie Pendergast
Jan 6, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Mikhail DoubrovinSteven M Larson

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