Abl promotes cadherin-dependent adhesion and signaling in myoblasts.

Cell Cycle
Min Lu, Robert S Krauss

Abstract

Cell-cell contact promotes myogenic differentiation but the mechanisms that regulate this phenomenon are not well understood. Cdo (also known as Cdon), an Ig superfamily member, functions as a component of cell surface complexes to promote myogenic differentiation through activation of p38alpha/beta MAP kinase. We recently showed that N-cadherin ligation activated p38alpha/beta in a Cdo-dependent manner, whereas N-cadherin ligation-dependent activation of ERK MAP kinase was not affected by loss of Cdo. The non-receptor tyrosine kinase Abl associates with Cdo during myoblast differentiation and is necessary for full activition of p38alpha/beta during this process. The Abl SH3 domain binds to a PxxP motif in the Cdo intracellular domain, and both these motifs are required for their promyogenic activity. Here we show that Abl is necessary for p38alpha/beta activation initiated by N-cadherin ligation, but in contrast to Cdo, Abl is also required for N-cadherin-dependent ERK activation. Moreover, Abl is required for efficient cadherin-mediated myoblast aggregation via modulation of RhoA-ROCK signaling. Therefore, Abl regulates N-cadherin-mediated p38alpha/beta activation by multiple mechanisms, more generally through regulation of c...Continue Reading

References

May 1, 1997·Developmental Biology·M George-WeinsteinK A Knudsen
Jul 28, 1997·The Journal of Cell Biology·C A CharltonH M Blau
Jul 27, 2002·Annual Review of Cell and Developmental Biology·Mary Elizabeth PownallCharles P Emerson
Sep 6, 2002·The Journal of Cell Biology·Sophie CharrasseCécile Gauthier-Rouvière
Oct 11, 2002·Advances in Cancer Research·Ann Marie Pendergast
Mar 14, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jong-Sun KangRobert S Krauss
Jan 7, 2004·Nature Reviews. Molecular Cell Biology·Oliver Hantschel, Giulio Superti-Furga
Jun 23, 2004·Nature Genetics·Cristiano SimonePier Lorenzo Puri
Aug 24, 2004·The Journal of Biological Chemistry·Tomoko NishiyamaAkira Kudo
Feb 19, 2005·The EMBO Journal·Frederic LluísPura Muñoz-Cánoves
Apr 1, 2006·The Journal of Biological Chemistry·Loriana CastellaniGermana Falcone
May 2, 2006·EMBO Reports·Maria Giovanna di BariDaniela Barilà
Oct 30, 2007·Proceedings of the National Academy of Sciences of the United States of America·Nicole L ZandyAnn Marie Pendergast
Mar 29, 2008·Cell Death and Differentiation·M FortierC Gauthier-Rouvière
Aug 6, 2008·The Journal of Cell Biology·Jong-Sun KangRobert S Krauss
Feb 27, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ji-Eun OhJong-Sun Kang
Feb 18, 2010·Proceedings of the National Academy of Sciences of the United States of America·Min Lu, Robert S Krauss

❮ Previous
Next ❯

Citations

Jul 24, 2014·Cellular Microbiology·Eike R HrinciusChristina Ehrhardt
Jun 18, 2017·Scientific Reports·Jinnan XiangHuijuan Liu
Mar 30, 2021·Frontiers in Cell and Developmental Biology·Fabián MontecinoHugo Olguín

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Signaling by Tyrosine Kinases

Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. RTKs have been shown not only to be key regulators of normal cellular processes but also to have a critical role in the development and progression of many types of cancer. Discover the latest research on cell signaling and RTK here.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Adherens Junctions

An adherens junction is defined as a cell junction whose cytoplasmic face is linked to the actin cytoskeleton. They can appear as bands encircling the cell (zonula adherens) or as spots of attachment to the extracellular matrix (adhesion plaques). Adherens junctions uniquely disassemble in uterine epithelial cells to allow the blastocyst to penetrate between epithelial cells. Discover the latest research on adherens junctions here.