PMID: 11345392May 10, 2001Paper

Ablation of atrial fibrillation in the rapid pacing canine model using a multi-electrode loop catheter

Journal of the American College of Cardiology
Boaz AvitallRay Helms

Abstract

This investigation details our experience using a loop catheter to ablate atrial fibrillation (AF) in dogs. Atrial fibrillation is the most common arrhythmia and has significant morbidity. Maintenance of normal sinus rhythm (NSR) after conversion in many patients is still a challenge. A multi-electrode loop catheter was used to create linear atrial lesions to ablate AF in a rapid atrial pacing model in 29 dogs. Rhythm status was assessed over a six-month recovery period, after which tissue analysis was performed. Acute conversion to NSR or atrial tachycardia (AT) was achieved in 90% of cases. Six of 26 conversions occurred after only left atrial (LA) lesions, and two after just right atrial lesions. Sixteen (62%) of 26 lesions that resulted in AF conversion were in the LA, and 11 of these 16 conversions occurred during a lesion connecting the mitral ring to the pulmonary veins. Acute conversion rate was similar with ring and coil electrodes, but AT was more frequent with coil electrodes (63% vs. 31%). At six months 80% of dogs were in NSR, 14% were in AT, and 7% remained in AF. There was an average reduction in P-wave amplitude of 64 +/- 26% after power application. Tissue analysis revealed transmural contiguous lesions when fi...Continue Reading

References

Oct 1, 1993·The Annals of Thoracic Surgery·J L CoxD G Lappas
Nov 1, 1995·Archives of Disease in Childhood·J V De Giovanni
Dec 1, 1996·Journal of Cardiovascular Electrophysiology·M HaïssaguerreJ Clémenty
Sep 3, 1998·The New England Journal of Medicine·M HaïssaguerreJ Clémenty
Mar 26, 1999·Journal of the American College of Cardiology·B AvitallG N Gupta

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Citations

Feb 7, 2012·Journal of Cardiovascular Medicine·Sen LeiYu Hou
Aug 17, 2006·Journal of Cardiovascular Electrophysiology·Thomas RostockMichel Haïssaguerre
Feb 6, 2017·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Boaz AvitallJosef Koblish
Jan 8, 2005·European Heart Journal·Thomas J van BrakelJos G Maessen
Jul 3, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Derek J DosdallNassir F Marrouche

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