Ablation of C/EBP homologous protein attenuates endoplasmic reticulum-mediated apoptosis and cardiac dysfunction induced by pressure overload

Circulation
Hai Ying FuTetsuo Minamino

Abstract

Apoptosis may contribute to the development of heart failure, but the role of apoptotic signaling initiated by the endoplasmic reticulum in this condition has not been well clarified. In myocardial samples from patients with heart failure, quantitative real-time polymerase chain reaction revealed an increase in messenger RNA for C/EBP homologous protein (CHOP), a transcriptional factor that mediates endoplasmic reticulum-initiated apoptotic cell death. We performed transverse aortic constriction or sham operation on wild-type (WT) and CHOP-deficient mice. The CHOP-deficient mice showed less cardiac hypertrophy, fibrosis, and cardiac dysfunction compared with WT mice at 4 weeks after transverse aortic constriction, although the contractility of isolated cardiomyocytes from CHOP-deficient mice was not significantly different from that in the WT mice. In the hearts of CHOP-deficient mice, phosphorylation of eukaryotic translation initiation factor 2alpha, which may reduce protein translation, was enhanced compared with WT mice. In the hearts of WT mice, CHOP-increased apoptotic cell death with activation of caspase-3 was observed at 4 weeks after transverse aortic constriction. In contrast, CHOP-deficient mice had less apoptotic c...Continue Reading

References

Sep 18, 1999·Cell·K R Chien
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Mar 14, 2002·Proceedings of the National Academy of Sciences of the United States of America·Tetsuo MinaminoMichael D Schneider
May 16, 2003·The New England Journal of Medicine·Mariell Jessup, Susan Brozena
Nov 25, 2003·Oncogene·David G BreckenridgeGordon C Shore
Dec 20, 2003·Cell Death and Differentiation·S Oyadomari, M Mori
Mar 23, 2004·Annals of the New York Academy of Sciences·Eva SzegezdiAfshin Samali
May 19, 2004·Journal of Neurochemistry·Xiongwei ZhuMark A Smith
Mar 15, 2005·The Journal of Clinical Investigation·Roger S-Y FooRichard N Kitsis
Oct 4, 2005·The Journal of Clinical Investigation·Chunyan XuJohn C Reed
Jun 15, 2007·Nature Reviews. Molecular Cell Biology·David Ron, Peter Walter
Jul 10, 2007·American Journal of Physiology. Heart and Circulatory Physiology·A K SharmaP K Singal
Sep 12, 2008·Proceedings of the National Academy of Sciences of the United States of America·John A MuraskiMark A Sussman
Apr 11, 2009·Apoptosis : an International Journal on Programmed Cell Death·Vanya I Rasheva, Pedro M Domingos

❮ Previous
Next ❯

Citations

Oct 2, 2013·Biological Trace Element Research·Su-Qin WangDeng-Feng Gao
Dec 23, 2011·Cell Death & Disease·M ChiongS Lavandero
Mar 3, 2011·Nature Cell Biology·Ira Tabas, David Ron
Apr 22, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·King-Tung ChinDavid Ron
Apr 27, 2012·Biochemistry Research International·Edward B Thorp
Jun 22, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Flori R SariKenichi Watanabe
Nov 19, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Christopher M Scull, Ira Tabas
Jun 16, 2012·PloS One·Vanessa García-RúaFrancisca Lago
Jun 4, 2014·PloS One·Christiane NeuberThomas Eschenhagen
Sep 4, 2013·International Journal of Molecular Sciences·Qiufang ZhangXuanbin Wang
Mar 4, 2014·Cardiovascular Research·Guido Tarone, Mara Brancaccio
Jul 14, 2014·Acta Biochimica Et Biophysica Sinica·Yiming LiZhinan Chen
Jan 6, 2016·International Journal of Molecular Sciences·Man Liu, Samuel C Dudley
Feb 4, 2016·International Journal of Molecular Sciences·Ekaterina A Ivanova, Alexander N Orekhov
Oct 27, 2015·International Journal of Molecular Medicine·Pingdong LinXihai Li
Jun 7, 2011·The American Journal of the Medical Sciences·Hong-Shan GuanShu-Bin Qiao
Feb 5, 2015·Cell Metabolism·Zhao V Wang, Joseph A Hill
Jun 9, 2015·Free Radical Biology & Medicine·Luciano CominaciniAnna Fratta Pasini
Jul 12, 2012·Free Radical Biology & Medicine·Guorui DouDavid R Hinton
Mar 19, 2014·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Yuzhen LiXiuhua Liu
Aug 31, 2013·Biochimica Et Biophysica Acta·Hery UrraClaudio Hetz
Jul 16, 2013·The Biochemical Journal·Darius J R LaneDes R Richardson
Mar 6, 2012·Pharmacology & Therapeutics·Adrienne M GormanAfshin Samali

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomegaly

Cardiomegaly, known as an enlarged heart, is a multifactorial disease with different pathophysiological mechanisms. Hypertension, pregnancy, exercise-induced and idiopathic causes are some mechanisms of cardiomegaly. Discover the latest research of cardiomegaly here.

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.