Ablation of sensory nerves favours melanoma progression.

Journal of Cellular and Molecular Medicine
Pedro H D M PrazeresAlexander Birbrair

Abstract

The tumour mass is composed not only of heterogeneous neoplastic cells, but also a variety of other components that may affect cancer cells behaviour. The lack of detailed knowledge about all the constituents of the tumour microenvironment restricts the design of effective treatments. Nerves have been reported to contribute to the growth and maintenance of numerous tissues. The effects of sensory innervations on tumour growth remain unclear. Here, by using state-of-the-art techniques, including Cre/loxP technologies, confocal microscopy, in vivo-tracing and chemical denervation, we revealed the presence of sensory nerves infiltrating within the melanoma microenvironment, and affecting cancer progression. Strikingly, melanoma growth in vivo was accelerated following genetic ablation or chemical denervation of sensory nerves. In humans, a retrospective analysis of melanoma patients revealed that increased expression of genes related to sensory nerves in tumours was associated with better clinical outcomes. These findings suggest that sensory innervations counteract melanoma progression. The emerging knowledge from this research provides a novel target in the tumour microenvironment for therapeutic benefit in cancer patients.

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Citations

Oct 4, 2020·Cellular and Molecular Neurobiology·Sara Santos BernardesAlexander Birbrair
Oct 29, 2020·Stem Cells Translational Medicine·Caroline C PicoliAlexander Birbrair
May 19, 2021·Histochemistry and Cell Biology·Isadora F G SenaAlexander Birbrair
May 19, 2021·Stem Cell Reviews and Reports·Leda M C Coimbra-CamposAlexander Birbrair
May 30, 2021·Critical Reviews in Oncology/hematology·Walison N SilvaAlexander Birbrair
Aug 14, 2021·Biochimica Et Biophysica Acta. Reviews on Cancer·Caroline C PicoliAlexander Birbrair
Nov 5, 2021·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Gabryella S P SantosAlexander Birbrair

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Methods Mentioned

BETA
dissection
biopsies

Software Mentioned

R2 Analysis and Visualization
Fiji

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