Ablation of type I hypersensitivity in experimental allergic conjunctivitis by eotaxin-1/CCR3 blockade.

International Immunology
Dai MiyazakiSanta Jeremy Ono

Abstract

The immune response is regulated, in part, by effector cells whose activation requires multiple signals. For example, T cells require signals emanating from the T cell antigen receptor and co-stimulatory molecules for full activation. Here, we present evidence indicating that IgE-mediated hypersensitivity reactions in vivo also require cognate signals to activate mast cells. Immediate hypersensitivity reactions in the conjunctiva are ablated in mice deficient in eotaxin-1, despite normal numbers of tissue mast cells and levels of IgE. To further define the co-stimulatory signals mediated by chemokine receptor 3 (CCR3), an eotaxin-1 receptor, effects of CCR3 blockade were tested with an allergic conjunctivitis model and in ex vivo isolated connective tissue-type mast cells. Our results show that CCR3 blockade significantly suppresses allergen-mediated hypersensitivity reactions as well as IgE-mediated mast cell degranulation. We propose that a co-stimulatory axis by CCR3, mainly stimulated by eotaxin-1, is pivotal in mast cell-mediated hypersensitivity reactions.

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Citations

Jun 12, 2014·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Simone EperonYan Guex-Crosier
Mar 26, 2014·Expert Opinion on Emerging Drugs·Erminia RidoloGiorgio Walter Canonica
Sep 16, 2011·Trends in Immunology·Sarah J CollingtonCharlotte L Weller
Jan 6, 2010·Immunology·Sarah J CollingtonCharlotte L Weller
May 15, 2013·The American Journal of Pathology·Dai MiyazakiYoshitsugu Inoue
Aug 8, 2009·The Journal of Allergy and Clinical Immunology·Ken FukudaSanta J Ono
Oct 30, 2016·Pharmacology & Therapeutics·Roopesh Singh GangwarFrancesca Levi-Schaffer
Dec 14, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chuan-Hui KuoSanta J Ono
Jul 22, 2009·Current Opinion in Allergy and Clinical Immunology·Ifeoma Offiah, Virginia L Calder
Aug 14, 2012·Current Opinion in Allergy and Clinical Immunology·Murat T Irkec, Banu Bozkurt
Jun 7, 2019·Current Opinion in Allergy and Clinical Immunology·Kara M CavuotoAnat Galor
Aug 20, 2009·Current Opinion in Allergy and Clinical Immunology

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