PMID: 6407860Jul 1, 1983Paper

Ablations of the mammillary nuclei in monkeys: effects on postoperative memory

Experimental Neurology
E J HolmesN Butters

Abstract

A new procedure was developed for ablating the mammillary nuclei in nonhuman primates via direct visual exposure. Using this technique, monkeys receiving lesions of the mammillary nuclei were compared to control animals after surgery to assess the retention of preoperatively acquired visuospatial discriminations and subsequent postoperative ability to attain a demanding spatial memory task. Although the lesions proved to be accurate and complete, no changes in gross behavior or deficits in preoperatively acquired visual and spatial behaviors were noted. The monkeys with mammillary body lesions were, however, impaired in their ability to acquire postoperatively the demanding spatial memory task. These findings are consistent with previous investigations suggesting that the mammillary bodies are involved in the acquisition of spatial discriminations and skills.

References

Sep 1, 1978·Brain : a Journal of Neurology·J A Horel
May 1, 1977·Experimental Neurology·J RosenstockE Greene
Apr 29, 1971·The New England Journal of Medicine·V Herbert
Jun 1, 1968·Brain : a Journal of Neurology·E E Krieckhaus, D Randall
Jun 1, 1967·Journal of Comparative and Physiological Psychology·C KimJ W Chu
Jun 25, 1982·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·M Mishkin
Mar 1, 1981·Brain : a Journal of Neurology·W A Lishman
May 1, 1954·Journal of Neurology, Neurosurgery, and Psychiatry·M WILLIAMS, J PENNYBACKER
Dec 1, 1956·A.M.A. Archives of Neurology and Psychiatry·N MALAMUD, S A SKILLICORN
May 1, 1961·Archives of Neurology·H CRAVIOTOJ SILBERMAN
Jan 1, 1963·Experimental Neurology·D W PLOOG, P D MACLEAN
Apr 1, 1963·Journal of Neurology, Neurosurgery, and Psychiatry·J BARBIZET
Oct 1, 1962·Archives of Neurology·D DAHLJ R KNOTT
Sep 1, 1964·Journal of Neurophysiology·E E KRIECKHAUS
Sep 1, 1964·Brain : a Journal of Neurology·R THOMPSONI RICH

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Citations

Nov 1, 1988·Neurotoxicology and Teratology·E D Levin, R E Bowman
Mar 1, 1992·Neurotoxicology and Teratology·E D LevinR E Bowman
Jul 14, 1999·Behavioural Brain Research·L J SantínJ L Arias
Feb 14, 1998·Progress in Neurobiology·V Sziklas, M Petrides
Mar 3, 1999·The European Journal of Neuroscience·V Sziklas, M Petrides
Jan 1, 1990·The European Journal of Neuroscience·S. SaravisM. Petrides
May 1, 1993·The European Journal of Neuroscience·V Sziklas, M Petrides
Jul 8, 2009·Pediatric Research·Rajesh KumarRonald M Harper
Oct 1, 1993·Neuropsychologia·J P Aggleton, A Sahgal
Nov 22, 2008·Neurobiology of Disease·Rajesh KumarRonald M Harper
Nov 3, 2009·Neuropsychologia·Seralynne D Vann
Jan 7, 2004·Nature Reviews. Neuroscience·Seralynne D Vann, John P Aggleton
Nov 8, 1990·The Journal of Comparative Neurology·G V Allen, D A Hopkins
Jan 22, 1993·The Journal of Comparative Neurology·L A MatsudaS J Lolait

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