PMID: 12780765Jun 5, 2003Paper

Abnormal 5-HT1D receptor function in cluster headache: a neuroendocrine study with sumatriptan

Cephalalgia : an International Journal of Headache
L PinessiP Limone

Abstract

The purpose of this study was to assess the sensitivity of 5-HT(1D) receptors in patients with episodic cluster headache using sumatriptan as a pharmacological probe. The drug, a selective 5-HT(1B/1D) agonist, stimulates the secretion of growth hormone and inhibits the release of prolactin, adrenocorticotropic hormone (ACTH) and cortisol. These effects may be used to explore the function of serotonergic systems in vivo. We administered subcutaneous sumatriptan and placebo to 20 patients with cluster headache (10 in the active phase and 10 in the remission period) and to 12 controls. The sumatriptan-induced increase of growth hormone concentrations was significantly (P < 0.05) blunted in patients with active cluster headache. Prolactin and ACTH responses to the drug were significantly (P < 0.05) reduced in patients with cluster headache, both in the active and in the remission period. Our results suggest that cerebral serotonergic functions mediated by 5-HT(1D) receptors are altered in patients with episodic cluster headache.

References

Dec 1, 1991·Cephalalgia : an International Journal of Headache·M LeoneG Bussone
Mar 1, 1987·Cephalalgia : an International Journal of Headache·E Waldenlind, S A Gustafsson
Mar 1, 1988·Cephalalgia : an International Journal of Headache·F SorgeP Carrieri
Jun 1, 1970·Journal of Consulting and Clinical Psychology·G J Allen
Jun 1, 1995·Cephalalgia : an International Journal of Headache·M LeoneG Bussone
Jan 1, 1995·Cephalalgia : an International Journal of Headache·M L GordonH M van Praag
Apr 1, 1995·British Journal of Clinical Pharmacology·S J EntwisleP S Freedman
Jan 1, 1994·Brain Research Bulletin·Q P Wang, Y Nakai
Feb 1, 1994·Neuropharmacology·R FranceschiniE Rolandi
Oct 1, 1993·Cephalalgia : an International Journal of Headache·M Leone, G Bussone
Feb 1, 1996·Cephalalgia : an International Journal of Headache·G BonoG Nappi
Nov 5, 1997·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·L N YathamI S Shiah
Nov 14, 1997·Cephalalgia : an International Journal of Headache·M LeoneG Bussone
Aug 5, 1998·Lancet·A MayP J Goadsby
Aug 5, 1998·Journal of Clinical Psychopharmacology·H J GijsmanG M Van Kempen
Feb 25, 2000·Neuroendocrinology·I ValverdeC Dieguez
Jun 1, 2000·Clinical and Experimental Pharmacology & Physiology·W F Ganong
Sep 22, 2000·Cephalalgia : an International Journal of Headache·L PinessiE Arvat
Feb 13, 2001·Cephalalgia : an International Journal of Headache·D W DodickS D Silberstein
Jun 16, 2001·Journal of Endocrinological Investigation·I RaineroP Limone
Dec 26, 2001·Current Pain and Headache Reports·Sheena K Aurora
Feb 23, 2002·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Tamara Pringsheim

❮ Previous
Next ❯

Citations

Jan 29, 2011·Current Pain and Headache Reports·Giorgio Lambru, Manjit Matharu
Jul 25, 2007·Cephalalgia : an International Journal of Headache·E L MeyerE Waldenlind
Mar 12, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Lee Butler, Karen Pilkington
Jan 18, 2013·Journal of Psychopharmacology·Marcos Gonçalves de RezendeCristina Marta Del-Ben
May 1, 2013·Cephalalgia : an International Journal of Headache·Anne LepperStefan Evers

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.