Abnormal access of axial vibrotactile input to deafferented somatosensory cortex in human upper limb amputees

Journal of Neurophysiology
J J KewD J Brooks

Abstract

We studied two human subjects with total deafferentation of one upper limb secondary to traumatic multiple cervical root avulsions. Both subjects developed a phantom limb and underwent elective amputation of the paralyzed, deafferentated limb. Psychophysical study revealed in each subject an area of skin in the pectoral region ipsilateral to the amputation where vibrotactile stimulation (VS) elicited referred sensations (RS) in the phantom limb. Positron emission tomography was then used to measure regional cerebral blood flow changes during VS of the pectoral region ipsilateral to the amputation with RS and during VS of a homologous part of the pectoral region adjacent to the intact arm without RS. A voxel-based correlation analysis was subsequently used to study functional connectivity. VS of the pectoral region adjacent to the intact arm was associated with activation of the dorsal part of the contralateral primary somatosensory cortex (S1) in a position consistent with the S1 trunk area. In contrast, VS of the pectoral region ipsilateral to the amputation with RS was associated with activation of the contralateral S1 that extended from the level of the trunk representation ventrally over distances of 20 and 12 mm, respectiv...Continue Reading

References

Jul 1, 1992·Neuroreport·V S RamachandranD C Rogers-Ramachandran
Nov 13, 1992·Science·V S RamachandranM Stewart
Aug 1, 1992·Physics in Medicine and Biology·T J SpinksJ Reed
Mar 12, 1992·Nature·C D Gilbert, T N Wiesel
Jul 1, 1992·Journal of Computer Assisted Tomography·R P WoodsJ C Mazziotta
Jun 1, 1992·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·J Katz
Jan 1, 1991·Somatosensory & Motor Research·P E GarraghtyJ H Kaas
Jul 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K J FristonR S Frackowiak
Jul 1, 1991·Journal of Computer Assisted Tomography·K J FristonR S Frackowiak
Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J V PardoM E Raichle
Jul 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K J FristonR S Frackowiak
Oct 1, 1989·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K J FristonR S Frackowiak
Jul 1, 1987·Journal of Neurosurgery·P T FoxM E Raichle
Oct 5, 1986·Nature·P T FoxD C Van Essen
Jan 1, 1967·Experimental Brain Research·A K McIntyreJ L Veale
Feb 1, 1980·Journal of Neurophysiology·R E BennettM Rowe
Mar 22, 1994·Proceedings. Biological Sciences·S AgliotiF Cortese
Jun 1, 1993·Brain : a Journal of Neurology·J P Brasil-NetoL G Cohen
Aug 1, 1996·Brain : a Journal of Neurology·S KnechtE Taub

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Citations

Feb 5, 1998·Nature·K D DavisJ O Dostrovsky
Feb 10, 2000·Journal of Computer Assisted Tomography·R I HenkinC S Lin
Dec 17, 2008·Brain : a Journal of Neurology·H Henrik EhrssonGöran Lundborg
Nov 15, 2013·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Zachary McCormickR Norman Harden
Sep 15, 1998·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·L G CohenC Butefisch
Jul 11, 2006·The Journal of Hand Surgery : Journal of the British Society for Surgery of the Hand·M HtutT Carlstedt
Mar 31, 2006·Cognitive Neuropsychiatry·Peter W Halligan
Mar 31, 2011·Disability and Rehabilitation·Laura P McAvinue, Ian H Robertson
Jun 10, 2009·Brain : a Journal of Neurology·V S Ramachandran, Eric L Altschuler
Oct 1, 2008·Acta Neuropsychiatrica·Abhishek SrivastavaP N Jayakumar
Feb 9, 2000·Perceptual and Motor Skills·G Grouios
Sep 26, 2013·Brain : a Journal of Neurology·G D Schott
Feb 28, 2002·Prosthetics and Orthotics International·C M FraserS G Kirker
Jan 11, 2005·Neuroreport·Sandra KampingStefan Knecht
Feb 24, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·C D FrithD M Wolpert
Dec 13, 2000·Proceedings of the National Academy of Sciences of the United States of America·C I MooreS Corkin
Dec 17, 1998·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·V S Ramachandran
Dec 6, 2003·The European Journal of Neuroscience·Christoph P HofstetterChristian Spenger
Sep 3, 2013·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Oliver H TurnbullMarilyn D Lucas
Oct 10, 1998·Neurologic Clinics·S M Weinstein

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