Abnormal Amygdala Resting-State Functional Connectivity in Irritable Bowel Syndrome.

AJNR. American Journal of Neuroradiology
Rongfeng QiG M Lu

Abstract

Functional neuroimaging studies in irritable bowel syndrome have revealed abnormalities in the corticolimbic regions, specifically, hyperactivity of the amygdala during visceral and somatic stimulation. This study investigated changes in the neural circuitry of the amygdala in patients with irritable bowel syndrome based on resting-state functional connectivity. Functional MR imaging data were acquired from 31 patients with irritable bowel syndrome and 32 healthy controls (matched for age, sex, and educational level) during rest, and the resting-state functional connectivity of bilateral amygdalae was compared. Multiple regression was performed to investigate the relationship between clinical indices of patients with irritable bowel syndrome and resting-state functional connectivity. Compared with healthy controls, patients with irritable bowel syndrome had higher positive resting-state functional connectivity between the amygdala and insula, midbrain, parahippocampal gyrus, pre- and postcentral gyri, and supplementary motor area. The inclusion of anxiety and depression as covariates did not alter amygdala resting-state functional connectivity differences between the study groups. Multiple covariate regression results showed th...Continue Reading

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Citations

Jul 5, 2017·Journal of Neurogastroenterology and Motility·Changhyun LeeUNKNOWN Brain-Gut Axis Research Group of Korean Society of Neurogastroenterology and Motility
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