Abnormal anterior chamber associated immune deviation (ACAID) in 129-strain mice

Ocular Immunology and Inflammation
J M HerndonRussell N Van Gelder

Abstract

To characterize anterior chamber immune deviation (ACAID) in 129-strain and mixed 129-strain mice. ACAID was assayed using standard protocols with herpes simplex-1 (HSV-1) and trinitrophenol-hapten-spleen cells (TNP-spleen) in C57B1/6, 129P2, 129X1, and intercrossed strains. Systemic tolerance induction was assayed using an ultraviolet light skin tolerance protocol to 2,-4,6-trinitro-l-chlorobenzene (TNCB). 129X1 and C57Bl/6xl29Xl Fl mice did not show ACAID to HSV-1. C57Bl/6xl29P2 mice did not show ACAID to TNP-spleen. C57Bl/6xl29P2 mice did show normal peripheral immune deviation to TNCB. (C57Bl/6xl29Xl) x C57B1/6 N2 backcrossed mice showed a bimodal ACAID response to HSV-1 suggesting a single dominant allele in the 129X1 background responsible for suppressing ACAID. ACAID to multiple antigens is significantly reduced in 129-strain mice and their outcrossed progeny. Since 129-strain embryonic stem cells are widely used to generate knockout and transgenic mice, care must be taken to extensively backcross resultant strains in order to assess the effect of particular genes on ACAID.

References

Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·B H KollerO Smithies
Jan 1, 1989·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·F G RobergeR B Nussenblatt
Nov 5, 1997·Ocular Immunology and Inflammation·T A Ferguson
Aug 3, 1999·Mammalian Genome : Official Journal of the International Mammalian Genome Society·M F FestingL E Mobraaten
Sep 27, 2000·Proceedings of the National Academy of Sciences of the United States of America·R SandbergC Barlow
Dec 6, 2000·Genesis : the Journal of Genetics and Development·S J Estill, J A Garcia
Mar 20, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·M E SkelseyJ Y Niederkorn
Mar 23, 2001·Ocular Immunology and Inflammation·D F ShenC C Chan
May 18, 2001·Diseases of the Colon and Rectum·A MularczykG Basilisco
Sep 7, 2001·Genome Research·V J BolivarL Flaherty
Jan 5, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Peter WhiteNancy E Cooke
May 9, 2002·Cornea·Koh-Hei Sonoda, Joan Stein-Streilein

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
Yalin RenAize Kijlstra
[Zhonghua yan ke za zhi] Chinese journal of ophthalmology
T FuZhen Zhang
© 2021 Meta ULC. All rights reserved