Abnormal anti-single stranded (ss) DNA activity in sera from Plasmodium falciparum infected individuals

Transactions of the Royal Society of Tropical Medicine and Hygiene
C Daniel RibeiroM Gentilini

Abstract

Sera from 32 subjects with Plasmodium falciparum parasitaemia were screened for the presence of antibodies to native-double stranded (ds) DNA and to heat-denaturated-single stranded (ss) DNA by a Farr DNA binding radioimmunoassay. In addition anti-dsDNA antibodies were also studied by indirect immunofluorescence using Crithidia luciliae and rat liver sections as substrates. Immunoglobulin (G, A, M) levels and plasmodial antibodies titres (PA) were concomitantly evaluated. The anti-ssDNA activity was higher in malarious individuals with high IgM levels than in normal or malarious individuals with normal IgM levels. This activity was higher during the acute stage of infection than after recovery. A positive and significant relationship was found between the anti-ssDNA activity and the IgM levels but not with IgG, IgA or PA titres. Speckled antinuclear antibodies (ANA) were also observed in sera from 43.8% of the individuals and the mean ssDNA activity was higher in these ANA positive patients. Conversely anti-dsDNA antibodies could not be detected by any of the tests performed. This preferential production of anti-ssDNA Ab and not anti-dsDNA Ab is additional evidence that the autoantibodies observed in malaria infection are not a...Continue Reading

References

Jan 1, 1979·Transactions of the Royal Society of Tropical Medicine and Hygiene·B M GreenwoodT A Platts-Mills
Dec 11, 1975·The Journal of Clinical Investigation·A D Bankhurst, R C Williams
Nov 1, 1972·The Journal of Clinical Pharmacology and New Drugs·J L ReidS D Vakil
Oct 1, 1969·Experimental Parasitology·J P Kreier, D A Dilley
Jan 1, 1983·Transactions of the Royal Society of Tropical Medicine and Hygiene·C Daniel-RibeiroM Gentilini
Feb 24, 1983·The New England Journal of Medicine·Y ShoenfeldR S Schwartz
Jan 1, 1982·International Archives of Allergy and Applied Immunology·A Escande, A Serre

❮ Previous
Next ❯

Citations

Apr 6, 2012·Immunologic Research·Toru AboHisami Watanabe
Apr 1, 1988·International Journal for Parasitology·C M RzepczykM P Alpers
Jan 1, 1990·Transactions of the Royal Society of Tropical Medicine and Hygiene·A Zumla
Sep 7, 2000·Acta Tropica·C T Daniel-Ribeiro, G Zanini
Aug 4, 2006·The Journal of Parasitology·Anoja AriyasingheToru Abo
Feb 13, 2016·Cell Host & Microbe·Cristina Fernandez-AriasAna Rodriguez
Feb 1, 1995·Baillière's Clinical Rheumatology·A O Adebajo, D A Isenberg
Sep 9, 2011·Memórias do Instituto Oswaldo Cruz·Karima BrahimiCláudio Tadeu Daniel-Ribeiro
Mar 25, 2000·Memórias do Instituto Oswaldo Cruz·C T Daniel-Ribeiro
Jun 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·M Kaiissar MannoorToru Abo
Jan 20, 2021·Journal of Leukocyte Biology·Debopam Ghosh, Jason S Stumhofer
Jul 1, 1990·Infection and Immunity·A O WozencraftV J Griffiths

❮ Previous
Next ❯