Abnormal antioxidant vitamin and carotenoid status in chronic renal failure

QJM : Monthly Journal of the Association of Physicians
T K HaM E Lean

Abstract

Oxidative modification of plasma lipoproteins increases their atherogenicity. Nutritive antioxidants, including carotenoids, can prevent such lipoperoxidation and may protect against atherosclerosis. Plasma retinol, ascorbate, alpha-tocopherol and four carotenoids (lutein, lycopene, alpha-carotene and beta-carotene) were measured using HPLC in 45 patients with chronic renal failure (CRF) and in 21 controls. Plasma retinol was significantly increased in patients with CRF (conservative therapy mean of 3.7 mumol/l vs. 1.9 mumol/l; p < 0.001). Plasma lycopene was significantly lower in patients with CRF (healthy mean 0.44 mumol/l vs. conservative therapy mean 0.27 mumol/l and haemodialysis mean of 0.17 mumol/l; p < 0.001), a finding that persisted even after adjusting for plasma cholesterol. Low circulating antioxidant lycopene levels may contribute to an already impaired antioxidant defence system in patients with CRF. The process of haemodialysis further compromises antioxidant defences, principally by removing water-soluble ascorbate and urate, but does not appear to affect circulating carotenoid concentrations.

Citations

Jul 10, 2002·Clinica Chimica Acta; International Journal of Clinical Chemistry·Cevahir ErdoğanSelda Bekpinar
Apr 20, 1999·Atherosclerosis·O HasselwanderI S Young
Sep 18, 2001·Lancet·S L NuttallD C Wheeler
Feb 2, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Warwick B DunnPaul Brenchley
Jan 18, 2008·Nephrology·John Kelly
Jul 12, 2012·International Journal of Clinical Practice·R HajhosseinyD J Goldsmith
Dec 8, 2007·American Journal of Nephrology·Ioannis KaramouzisDimitrios M Grekas
Jan 5, 2013·International Journal of Medical Sciences·Chih-Hung Guo, Chia-Liang Wang
Oct 23, 2012·Indian Journal of Nephrology·P RamakrishnaV Sivakumar
Sep 11, 1998·Free Radical Research·O Hasselwander, I S Young
Feb 13, 2001·Kidney International. Supplement·M MydlíkJ Petrovicová
Apr 25, 2001·Kidney International·G J HandelmanJ B Blumberg
Oct 7, 2011·Kidney International·Jeff S Coombes, Robert G Fassett
Mar 6, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Jing ChenPaul K Whelton
Jan 7, 2004·Advances in Renal Replacement Therapy·Kamyar Kalantar-Zadeh, Joel D Kopple
Jan 10, 2002·Redox Report : Communications in Free Radical Research·P V Srinivasa RaoL Jayaseelan
Feb 24, 2001·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·R MacGinleyA P Disney
Aug 4, 2006·American Journal of Physiology. Renal Physiology·Kim E JieBranko Braam
Dec 24, 2004·European Heart Journal·Lennart G BongartzBranko Braam
Aug 4, 2007·The International Journal of Artificial Organs·G TsagalisN Zerefos
Jun 21, 2002·The International Journal of Artificial Organs·M MydlíkM Hríbiková
Apr 30, 2021·Photodiagnosis and Photodynamic Therapy·Rui GaoXiaoyi Lv
Dec 1, 2001·Journal of the American Society of Nephrology : JASN·Margus AnnukBengt Fellström

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