Abnormal auditory N400 in a case of zolpidem dependence, during a working memory test

European Psychiatry : the Journal of the Association of European Psychiatrists
Ioannis A LiappasAndreas D Rabavilas

Abstract

Zolpidem is a GABA (A) agonist, which is indicated for the short-term management of insomnia. Recent research provide evidence suggesting that zolpidem produces spatial working memory (WM) deficits and dependence; however, the underlying mechanisms of these effects are unknown. Since the auditory N400 component of event-related potentials (ERPS) is considered as an index of memory use of context processing, the present study focused on N400 waveform of ERPs elicited during a WM task in a case suffering from zolpidem dependence. The patterns of N400 waveform of this case were compared to the patterns obtained from healthy controls. This comparison revealed that zolpidem dependence is accompanied by reduced amplitudes located at posterior brain areas and diffuse prolongation of N400. These findings may indicate that zolpidem dependence manifests alterations with regard to the memory use of context processing, involving or affecting a wide-ranging network of the brain's structures.

References

Mar 1, 1995·Electroencephalography and Clinical Neurophysiology·L L ChaoR T Knight
Aug 30, 2002·Psychonomic Bulletin & Review·L JenkinsA F Fry
Jul 16, 2003·Psychiatry Research·Charalabos C Papageorgiou, Andreas D Rabavilas

❮ Previous
Next ❯

Citations

Jul 24, 2013·European Journal of Clinical Pharmacology·Caroline Victorri-VigneauP Jolliet
Jan 29, 2014·Journal of Addictive Diseases·Caroline Victorri-VigneauPascale Jolliet

❮ Previous
Next ❯

Related Concepts

Related Feeds

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.