PMID: 6114922May 1, 1981Paper

Abnormal baroreflex control of heart rate in prehypertensive and hypertensive Dahl genetically salt-sensitive rats

Hypertension
F J GordonA L Mark

Abstract

This study tested the hypothesis that in the Dahl model of genetic hypertension abnormal baroreflex function may precede and contribute to the development of hypertension. Sensitivity of baroreflex control of heart rate was assessed in conscious sensitive (S) and resistant (R) Dahl rats fed a high or low salt diet. Sensitivity of baroreflex control of heart rate was lower in S rats fed low salt although arterial pressure was not different from that of R rats. Hypertensive S rats showed resetting of baroreflexes to the higher pressure level without any further change in sensitivity. Pressor responses to phenylephrine were augmented in both prehypertensive and hypertensive S rats compared to R rats. Ganglionic blockade abolished this difference. In hypertensive S rats, ganglionic blockade decreased arterial pressure to levels not different than similarly treated R rats, indicating that neurogenic mechanisms contribute importantly to the early stages of hypertension in the Dahl model. These studies have identified impaired baroreflex function in prehypertensive and hypertensive Dahl S rats. This defect augments responses to pressor stimuli and may contribute to the development of salt-induced hypertension in the Dahl strain.

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Citations

Jul 1, 1992·Hypertension·C Hinojosa-LabordeJ R Haywood
Jan 1, 1991·Clinical and Experimental Hypertension. Part A, Theory and Practice·J D Peuler
Aug 1, 1992·Clinical and Experimental Pharmacology & Physiology·G A Head, M A Adams
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Aug 1, 1995·Clinical and Experimental Hypertension : CHE·M TozawaK Fukiyama
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Mar 30, 2017·Cellular and Molecular Neurobiology·Michael J HuberZhiying Shan
Sep 1, 1992·Hypertension·S R Reddy, T A Kotchen
Jan 1, 1984·Clinical and Experimental Hypertension. Part A, Theory and Practice·F M Abboud
Nov 1, 1983·Hypertension·B H MachadoE M Krieger
Jan 21, 2000·Hypertension·C Hinojosa-LabordeJ R Haywood
Feb 21, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·G S GopalakrishnanM E Symonds
Oct 7, 2015·Clinical and Experimental Pharmacology & Physiology·Elaine F SilvaGustavo R Pedrino
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Jun 1, 1992·Hypertension·J W Osborn, B J Provo
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Aug 18, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jeffrey L SegarFred S Lamb

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