Abnormal behaviors in the calibration curves of liquid chromatography-tandem mass spectrometry occurring in the quantitative analysis of surfactants near critical micelle concentrations.

Journal of Mass Spectrometry : JMS
Sang Tak LeeHan Bin Oh

Abstract

Surfactants, including quaternary ammonium compounds, are widely used in daily life as part of consumer chemical products and, more recently, in the shale oil industry. Because of their unique amphiphilic properties, surfactants form micelles at concentrations above a certain threshold known as the critical micelle concentration (CMC). A previous electrospray ionization mass spectrometry studies conducted by Siuzdak et al. and others presented indirect evidence regarding micelle formation. Herein, we have used liquid chromatography-tandem mass spectrometry to explore how such micelle formations affect the quantitative analysis of surfactants. Results reveal abnormal behaviors in the calibration plots of a few selected anionic and cationic surfactants, such as sodium decyl sulfate (SDeS), sodium dodecyl sulfate (SDS), myristyltrimethylammonium bromide (MTAB), and benzyldimethyloctadecylammonium chloride (BAC-18). At concentrations close to the respective CMCs of these surfactants, the calibration plot for MTAB flattened, whereas the slopes of the calibration plots for SDeS, SDS, and BAC-18 suddenly changed. These abnormal behaviors can be related to micelle formation. From a practical perspective, the above observations suggest ...Continue Reading

References

Nov 17, 2006·Journal of Colloid and Interface Science·A C S NevesV M M Lobo
May 22, 2007·Journal of Colloid and Interface Science·Tine-Martin Perger, Marija Bester-Rogac
Jun 26, 2007·Journal of the American Chemical Society·Michal SharonCarol V Robinson
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Jan 26, 2012·European Journal of Mass Spectrometry·Leopoldo CerauloSergio Indelicato
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Mar 31, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Evelin FarsangKrisztián Horváth

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