Abnormal Blink Reflex and Intermuscular Coherence in Writer's Cramp.

Frontiers in Neurology
Supriyo ChoudhuryStuart N Baker

Abstract

Background: Writer's cramp (WC) is a task-specific focal hand dystonia presenting with pain, stiffness and/or tremor while writing. We explored the involvement of cortical and brainstem circuits by measuring intermuscular coherence (IMC) and pre-pulse inhibition (PPI) of the blink reflex. Methods: IMC was measured in 10 healthy controls and 20 WC patients (10 with associated tremor) while they performed a precision grip task at different force levels. Blink responses were evaluated in 9 healthy controls and 10 WC patients by stimulating the right supraorbital nerve and recording surface EMG from the orbicularis oculi muscles bilaterally. PPI involved conditioning this stimulation with a prior shock to the right median nerve (100 ms interval), and measuring the reduction in the R2 component of the blink reflex. Results: Significant IMC at 3-7 Hz was present in WC patients, but not in healthy controls. Compared to healthy controls, in WC patients the R2 component of the blink reflex showed significantly less PPI. IMC at 3-7 Hz could reliably discriminate WC patients from healthy controls. Conclusion: Cortical or sub-cortical circuits generating theta (3-7 Hz) oscillations might play an important role in the pathogenesis of WC. Mo...Continue Reading

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Citations

Aug 2, 2018·Journal of Neurophysiology·Stefane A AguiarChristine K Thomas
Oct 10, 2020·Movement Disorders Clinical Practice·Alexis F CollinsMark R Baker
Mar 9, 2021·PLoS Computational Biology·Akira NagamoriFrancisco J Valero-Cuevas

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