Abnormal bone remodelling and increased levels of macrophage inflammatory protein-1 alpha (MIP-1alpha) in Waldenström macroglobulinaemia

British Journal of Haematology
Evangelos TerposMeletios-Athanassios Dimopoulos

Abstract

Serum levels of macrophage inflammatory protein-1 alpha (MIP-1alpha) and bone remodelling markers were evaluated in 38 patients with Waldenström macroglobulinaemia (WM) and correlated with clinical and laboratory variables. MIP-1alpha was elevated in WM; untreated patients had higher MIP-1alpha levels than patients in remission or with active disease after treatment. MIP-1alpha correlated with increased bone resorption, beta2-microglobulin and splenomegaly. Receptor activator of nuclear factor-kappaB ligand serum levels were elevated in WM patients; the subsequent increased bone resorption was balanced by a comparable elevation of osteoprotegerin production and bone formation. These findings may explain the absence of lytic lesions in WM patients and suggest a potential role of MIP-1alpha in WM.

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Citations

Apr 14, 2010·Biomarkers in Medicine·Craig S MillerJohn T McDevitt
Mar 11, 2010·Leukemia & Lymphoma·Sherry T ShuThomas J Rosol
Apr 14, 2009·Clinical Lymphoma & Myeloma·Sherine F Elsawa, Stephen M Ansell
Apr 2, 2011·Clinical Lymphoma, Myeloma & Leukemia·Irene M GhobrialAldo Roccaro
Mar 16, 2013·Clinical Lymphoma, Myeloma & Leukemia·Amit Agarwal, Irene M Ghobrial
Nov 9, 2016·Best Practice & Research. Clinical Haematology·Shahrzad Jalali, Stephen M Ansell
Aug 15, 2018·Blood Advances·Shahrzad JalaliStephen M Ansell
Jan 1, 2014·Clinical and Translational Allergy·Heleen D de Koning

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