Abnormal brain activation and connectivity to standardized disorder-related visual scenes in social anxiety disorder

Human Brain Mapping
Carina Y HeitmannThomas Straube

Abstract

Our understanding of altered emotional processing in social anxiety disorder (SAD) is hampered by a heterogeneity of findings, which is probably due to the vastly different methods and materials used so far. This is why the present functional magnetic resonance imaging (fMRI) study investigated immediate disorder-related threat processing in 30 SAD patients and 30 healthy controls (HC) with a novel, standardized set of highly ecologically valid, disorder-related complex visual scenes. SAD patients rated disorder-related as compared with neutral scenes as more unpleasant, arousing and anxiety-inducing than HC. On the neural level, disorder-related as compared with neutral scenes evoked differential responses in SAD patients in a widespread emotion processing network including (para-)limbic structures (e.g. amygdala, insula, thalamus, globus pallidus) and cortical regions (e.g. dorsomedial prefrontal cortex (dmPFC), posterior cingulate cortex (PCC), and precuneus). Functional connectivity analysis yielded an altered interplay between PCC/precuneus and paralimbic (insula) as well as cortical regions (dmPFC, precuneus) in SAD patients, which emphasizes a central role for PCC/precuneus in disorder-related scene processing. Hyperconn...Continue Reading

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Citations

Nov 10, 2016·Medicine·Reza TadayonnejadKinh Luan Phan
May 31, 2017·ELife·Nicholas L BalderstonChristian Grillon
Jan 29, 2019·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Hyung-Jun YoonIl Han Choo
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Apr 10, 2020·F1000Research·Janna Marie Bas-Hoogendam, P Michiel Westenberg
Jun 22, 2018·Annals of Clinical and Translational Neurology·Pauline PoppMarianne Dieterich
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Jun 3, 2021·International Journal of Environmental Research and Public Health·Xianglian YuLin Zhang
Jul 21, 2021·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Lorenzo Lucherini AngelettiGeorg Northoff

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