Abnormal coactivation of the hypothalamus and salience network in patients with cluster headache

Neurology
En-chao QiuSheng-yuan Yu

Abstract

The purpose of this study was to investigate whether the resting-state coactivation of the hypothalamus, both ipsilateral and contralateral to the headache side, and the salience network (SN) was altered in patients with cluster headache (CH) in the headache attack remission state in the cluster period, and to reveal possible pathogenesis of CH attacks and gain further insight into the pathophysiology of CH. Resting-state fMRI scans of 21 patients with CH were obtained (13 with right-sided headache and 8 with left-sided headache) and 21 age- and sex-matched normal controls. The resting-state fMRI data were analyzed using independent component analysis to identify the group differences of hypothalamic-SN coactivation between the patients with CH and healthy controls. Decreased functional coactivation was detected between the hypothalamus, both ipsilateral and contralateral to the headache side, and the SN both in patients with right-sided CH and in those with left-sided CH. Our findings suggest that the decreased hypothalamus-SN coactivation may have a role in CH attacks by the defective central pathway of pain control and autonomic nervous system dysregulation. This helps to gain additional insight into the pathophysiologic bas...Continue Reading

Citations

Dec 17, 2015·Brain Structure & Function·Kasey S HemingtonKaren D Davis
Jul 6, 2017·Cephalalgia : an International Journal of Headache·Fu-Chi YangShuu-Jiun Wang
Sep 9, 2016·Cephalalgia : an International Journal of Headache·Kun-Hsien ChouChing-Po Lin
Nov 21, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Catherine D ChongAnders Hougaard
Jun 1, 2018·Expert Opinion on Drug Safety·Antonio Riccardo BuonomoIvan Gentile
Jun 14, 2018·The Neuroradiology Journal·Nina VenturaEmerson L Gasparetto
Mar 2, 2018·Nature Reviews. Disease Primers·Arne MayShuu-Jiun Wang
Jan 28, 2017·Headache·Miguel Ja Láinez, Edelmira Guillamón
Apr 2, 2020·The Journal of Headache and Pain·Laura H SchulteArne May
Jun 28, 2019·Frontiers in Neurology·Zhiye ChenShengyuan Yu
Jul 23, 2020·Frontiers in Neurology·Stefania FerraroMassimo Leone
May 19, 2021·Neurology India·Steffen Naegel, Mark Obermann
Aug 14, 2021·The Journal of Headache and Pain·Sonia MedinaMatthew A Howard

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