Abnormal default-mode network in angiotensin converting enzyme D allele carriers with remitted geriatric depression

Behavioural Brain Research
Zan WangZhijun Zhang

Abstract

Using a cross-sectional case-control study of remitted geriatric depression (RGD), we characterised the relationships among cognitive function, whole-brain functional connectivity of the posterior cingulate cortex (PCC), and the angiotensin-converting enzyme (ACE) insertion or deletion (I/D) polymorphism during resting state. A total of 26 RGD patients and 24 matched controls were recruited, and neuropsychological tests, functional magnetic resonance imaging (fMRI) and ACE I/D genotype were examined for each subject. A 2 × 2 factorial analysis of variance (ANOVA) model (presence/absence of depression and presence/absence of ACE-D) was used to detect the interaction effect. Subsequent analyses were restricted to the significant interaction regions. There were significant interactions between disease and genotype at two clusters: left superior temporal gyrus/middle temporal gyrus and left cerebellum. And the ACE I/D polymorphism has disease-specific effects on the left superior temporal gyrus/middle temporal gyrus and cerebellum crus I. Furthermore, there was a significant positive correlation between the functional connection of PCC-left cerebellum crus I and the CFT-delayed recall test scores (r=0.668, P=0.003) in RGD group ACE...Continue Reading

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Citations

Feb 27, 2013·Molecular Psychiatry·W D TaylorG S Alexopoulos
Jan 9, 2013·Brain Connectivity·Chandan J Vaidya, Evan M Gordon
Dec 3, 2014·Biological Psychiatry·Qiyong Gong, Yong He
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Mar 5, 2014·Clinical EEG and Neuroscience·Rex L CannonJacob J Levy
Feb 25, 2018·CNS Neuroscience & Therapeutics·Hui-Feng ZhangDai-Hui Peng
Aug 2, 2017·BMC Medicine·João VianBrisa S Fernandes

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