PMID: 9164482May 1, 1997Paper

Abnormal DNA repair activities in lymphocytes of workers exposed to 1,3-butadiene

Mutation Research
L M HallbergW W Au

Abstract

Exposure to high concentrations of butadiene has been shown to cause cancer among exposed workers. We have conducted a biomarker study to elucidate whether current butadiene exposure conditions are hazardous to workers. Twenty-four workers exposed consistently to butadiene were matched with 19 co-workers who had much less contact with butadiene and who served as our controls. In the standard cytogenetic assay, there was no difference in chromosome aberration frequencies between the exposed and control groups. In the challenge assay, the exposed group shows a consistent, but non-significant, increase in chromosome aberrations indicating some abnormality in DNA repair response. The observed dicentric frequency in the challenge assay (indicative of abnormal repair of damaged chromosomes) is significantly correlated with a butadiene metabolite, 1,2-dihydroxy-4-(N-acetylcysteinyl)butane, in urine (r = 0.52; p = 0.04). Furthermore, cigarette smokers had consistently abnormal repair response compared with non-smokers for both the control and exposed groups. A small subset of the studied workers were evaluated for toxicant-induced DNA repair deficiency using an independent cat-host cell reactivation (CAT-HCR) assay. When cigarette smok...Continue Reading

References

Jun 1, 1992·Mutation Research·M Sasiadek

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Citations

Dec 4, 2003·Mutation Research·William W Au
Jun 9, 2001·Chemico-biological Interactions·K HughesM Walker
Jun 9, 2001·Chemico-biological Interactions·R B HayesM T Smith
Aug 2, 2003·Cancer Detection and Prevention·P VodickaK Hemminki
Feb 18, 2003·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·K HughesR Beauchamp
Nov 25, 2003·Environmental Health Perspectives·William W AuCarlos H Sierra-Torres
Dec 5, 2013·PloS One·Gemma MonyarchCarme Fuster
Aug 8, 2009·Reviews on Environmental Health·William W Au, Mathuros Ruchirawat
Dec 9, 2000·Analytical Biochemistry·A Roguev, G Russev
Feb 24, 2016·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Patricia I Mathias, Clayton B'hymer
Apr 3, 2013·International Journal of Hygiene and Environmental Health·Mathuros RuchirawatWilliam W Au
Dec 19, 2006·International Journal of Hygiene and Environmental Health·William W Au
Apr 24, 2007·Analytical Biochemistry·Hyun-Wook LeeTimothy R O'Connor
Oct 13, 2009·International Journal of Hygiene and Environmental Health·William W AuMathuros Ruchirawat
Jun 19, 2001·Rapid Communications in Mass Spectrometry : RCM·N B CechC G Enke
Oct 8, 2004·Environmental and Molecular Mutagenesis·Pavel VodickaKari Hemminki
Sep 28, 2010·Critical Reviews in Toxicology·Richard J AlbertiniMichael L Gargas
Feb 26, 2010·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·Avinash M Topè, Phyllis F Rogers
Jun 29, 1999·Analytical Chemistry·W M DraperP R Michael
May 19, 2010·Mutation Research·Ilse DecordierMicheline Kirsch-Volders

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