Get paper from

journal cover

Abnormal dosage of ultraconserved elements is highly disfavored in healthy cells but not cancer cells

PLoS Genetics

Oct 1, 2014

Ruth B. McColeC-ting Wu

Get paper from

Abstract

Ultraconserved elements (UCEs) are strongly depleted from segmental duplications and copy number variations (CNVs) in the human genome, suggesting that deletion or duplication of a UCE can be deleterious to the mammalian cell. Here we address the process by which CNVs become depleted of...read more

Mentioned in this Paper

Enhancer brand
DNA Sequence
Alcohol Related Neurodevelopmental Disorder
Gene Dosage
Homologous Gene
Purge
Tumor Cells, Malignant
DNA Copy Number Variations
Mammalian Cell
Mutation Abnormality
9
39
1
Paper Details
References

Abnormal dosage of ultraconserved elements is highly disfavored in healthy cells but not cancer cells

PLoS Genetics

Oct 1, 2014

Ruth B. McColeC-ting Wu

PMID: 25340765

DOI: 10.1371/journal.pgen.1004646

Abstract

Ultraconserved elements (UCEs) are strongly depleted from segmental duplications and copy number variations (CNVs) in the human genome, suggesting that deletion or duplication of a UCE can be deleterious to the mammalian cell. Here we address the process by which CNVs become depleted of...read more

Mentioned in this Paper

Enhancer brand
DNA Sequence
Alcohol Related Neurodevelopmental Disorder
Gene Dosage
Homologous Gene
9
39
1

Related Papers

Paper Details
References

Get paper from

/papers/abnormal-dosage-of-ultraconserved-elements-is/25340765