Abnormal dynamic functional connectivity between speech and auditory areas in schizophrenia patients with auditory hallucinations

NeuroImage. Clinical
Wenjing ZhangSu Lui

Abstract

Auditory hallucinations (AH), typically hearing voices, are a core symptom in schizophrenia. They may result from deficits in dynamic functional connectivity (FC) between cortical regions supporting speech production and language perception that interfere with the ability to recognize self-generated speech as not coming from external sources. We tested this hypothesis by investigating dynamic connectivity between the frontal cortex region related to language production and the temporal cortex region related to auditory processing. Resting-state fMRI scans were acquired from 18 schizophrenia patients with AH (AH+), 17 schizophrenia patients without AH (AH-) and 22 healthy controls. A multiband sequence with TR = 427 ms was adopted to provide relatively high temporal resolution data for characterizing dynamic FC. Analysis focused on connectivity between speech production and language comprehension areas, eloquent language cortex in the left hemisphere. Two frequency bands of brain oscillatory activity were evaluated (0.01-0.027 Hz, 0.027-0.08 Hz) in which differential alterations that have been previously linked to schizophrenia. Conventional static FC maps of these seeds were also calculated. Dynamic connectivity analysis indica...Continue Reading

Citations

Jun 7, 2019·The British Journal of Radiology·Xiaoqi HuangBharat B Biswal
Dec 8, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Wenjing ZhangJohn A Sweeney
May 1, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Wenjing ZhangFabiano G Nery
Aug 20, 2020·Brain Structure & Function·Haiyang GengBranislava Ćurčić-Blake
Oct 11, 2020·Brain Imaging and Behavior·Qiang WangGui Xue
Aug 14, 2020·Social Cognitive and Affective Neuroscience·Armin IrajiVince D Calhoun
Feb 2, 2021·Human Brain Mapping·Lekai LuoQiyong Gong
Jul 20, 2020·Trends in Neurosciences·Thomas A W BoltonDimitri Van De Ville
Jun 29, 2021·Frontiers in Psychiatry·Steven M Silverstein, Adriann Lai
Jul 20, 2021·Frontiers in Human Neuroscience·Leyi FanSiyang Luo

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