Abnormal EBV immune status in oral lichen planus

Oral Diseases
A Pedersen

Abstract

To investigate any possible association between oral lichen planus (OLP) and the humoral immune response to Epstein-Barr virus (EBV). The population consisted of 22 patients with histologically verified OLP and 22 healthy sex- and age-matched controls without any oral mucosal diseases. Specific serum IgG antibodies (Ab) towards EBV early antigen (EA) and nuclear antigen-I (EBNA) and IgM Ab towards EBV EA were determined by ELISA. The optometric density (OD) IgG anti-EA Ab levels were significantly higher in OLP patients than in controls and a significantly negative correlation between duration of symptoms from OLP and IgG anti-EA OD Ab values was demonstrated. IgM anti-EA and IgG anti-EBNA OD Ab levels were not significantly different between the two groups. The hypothesis of any possible association between EBV and OLP has never been tested but the present results seem to lend support for an aberration in the humoral response to EBV in OLP patients.

References

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Citations

May 16, 2003·Journal of Periodontology·Laurence BunetelMartine Bonnaure-Mallet
Jul 14, 2018·Journal of Dental Research·H RaybaudA Doglio
Nov 27, 2019·International Journal of Molecular Sciences·Lilit TonoyanAlain Doglio
Jul 29, 1998·Oral Diseases·A Pedersen
Mar 6, 1998·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·C ScullyD Wray
Oct 29, 2003·Molecular Diagnosis : a Journal Devoted to the Understanding of Human Disease Through the Clinical Application of Molecular Biology·Cathal OFlathartaMohamed J E M F Mabruk
Aug 4, 2020·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Sajna AshrafKamran Habib Awan

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