Abnormal Epigenetic Regulation of Immune System during Aging

Frontiers in Immunology
Miriam G Jasiulionis

Abstract

Epigenetics refers to the study of mechanisms controlling the chromatin structure, which has fundamental role in the regulation of gene expression and genome stability. Epigenetic marks, such as DNA methylation and histone modifications, are established during embryonic development and epigenetic profiles are stably inherited during mitosis, ensuring cell differentiation and fate. Under the effect of intrinsic and extrinsic factors, such as metabolic profile, hormones, nutrition, drugs, smoke, and stress, epigenetic marks are actively modulated. In this sense, the lifestyle may affect significantly the epigenome, and as a result, the gene expression profile and cell function. Epigenetic alterations are a hallmark of aging and diseases, such as cancer. Among biological systems compromised with aging is the decline of immune response. Different regulators of immune response have their promoters and enhancers susceptible to the modulation by epigenetic marks, which is fundamental to the differentiation and function of immune cells. Consistent evidence has showed the regulation of innate immune cells, and T and B lymphocytes by epigenetic mechanisms. Therefore, age-dependent alterations in epigenetic marks may result in the decline...Continue Reading

References

Jan 30, 1990·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·T H Bestor
Jan 1, 1983·Annals of the New York Academy of Sciences·N R KlinmanD Zharhary
Mar 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·P A Jones, M L Gonzalgo
Dec 10, 1999·Cell·A P Bird, A P Wolffe
Aug 12, 2000·Journal of Clinical Immunology·R Aspinall, D Andrew
May 31, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·R YungB Richardson
Aug 11, 2001·Science·P A Jones, D Takai
May 22, 2002·Mechanisms of Ageing and Development·Zhiyong ZhangBruce Richardson
Oct 31, 2002·International Immunology·Kara M JohnsonPamela L Witte
Aug 27, 2003·Nature·Konrad T HowitzDavid A Sinclair
Oct 28, 2003·Molecular and Cellular Biochemistry·Mark A CasillasTrygve O Tollefsbol
May 28, 2004·Nature·Gerda EggerPeter A Jones
Apr 9, 2005·Nature Reviews. Genetics·Wolf Reik, Annabelle Lewis
Jun 15, 2005·Annual Review of Biochemistry·Mary Grace Goll, Timothy H Bestor
Jul 13, 2005·Proceedings of the National Academy of Sciences of the United States of America·Mario F FragaManel Esteller
Dec 13, 2005·Science·Danica ChenLeonard Guarente
Feb 18, 2006·Proceedings of the National Academy of Sciences of the United States of America·Ian C G WeaverMoshe Szyf
Feb 24, 2006·Proceedings of the National Academy of Sciences of the United States of America·Chance John LuckeyDiane Mathis
Feb 25, 2006·Cell·Shizuo AkiraOsamu Takeuchi
Jul 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·John K NorthropHao Shen
Jul 28, 2006·Trends in Immunology·Kenneth L Wright, Jenny P-Y Ting
Nov 7, 2006·Nature·Joseph A BaurDavid A Sinclair
Feb 3, 2007·Molecular & Cellular Proteomics : MCP·Yue ChenYingming Zhao
Feb 27, 2007·Cell·Bing LiJerry L Workman
Apr 7, 2007·Pediatric Research·Pernille PoulsenMario F Fraga
Apr 25, 2007·The Journal of Experimental Medicine·Elizabeth E CrouchRafael Casellas
May 23, 2007·Molecular and Cellular Biology·K E SullivanM Bhatia
Jun 1, 2007·Nature·Simmie L FosterRuslan Medzhitov
Aug 3, 2007·Genes & Development·Nicolas GévryLuc Gaudreau
Aug 7, 2007·PLoS Biology·Stuart M ChambersMargaret A Goodell

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Citations

Jun 13, 2018·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Yukihiro Itoh
Jun 5, 2019·Nutrients·Agnieszka Gadecka, Anna Bielak-Zmijewska
Jan 25, 2020·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Frank Comhaire, Wim Decleer
Jun 20, 2019·Frontiers in Immunology·Giselle M BoukhaledConnie M Krawczyk
Jul 30, 2019·Frontiers in Cell and Developmental Biology·Jorge Martínez-CanoCésar Cobaleda
Dec 14, 2018·Frontiers in Genetics·Alexander Vaiserman
May 22, 2019·Frontiers in Endocrinology·Maunil K Desai, Roberta Diaz Brinton
Apr 2, 2020·Frontiers in Immunology·Salwan Al-NasiryBoris W Kramer
Jun 28, 2018·Journal of Leukocyte Biology·Jörg J GoronzyCornelia M Weyand
Jun 25, 2020·The FEBS Journal·Shuhei KobayashiYuji Owada
Oct 30, 2020·Frontiers in Cell and Developmental Biology·Panxia WangPeiqing Liu
Apr 9, 2021·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Francesco CataniaLe Anh Nguyen Long
Apr 20, 2021·Frontiers in Immunology·Yunkai Yang, Yan Wang
Jun 3, 2021·Journal of Developmental Biology·Rwik Sen, Christopher Barnes
Jul 20, 2021·Ageing Research Reviews·Simone BorgoniJoão Pedro de Magalhães
Jul 30, 2021·Frontiers in Medicine·Renata Brito Falcão-HolandaReinaldo Salomão
Jul 29, 2021·NPJ Vaccines·Béatrice LaupèzeRobbert Van der Most
Dec 16, 2021·Clinical Reviews in Allergy & Immunology·Ozlem BulutJorge Domínguez-Andrés

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Methods Mentioned

BETA
deamination
acetylation
ribosylation
histone acetylation

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