PMID: 3384180Jun 1, 1988Paper

Abnormal erythrocyte charge in diabetes mellitus. Link with microalbuminuria

Diabetes
G GambaroG Crepaldi

Abstract

The anionic charge on the surface of the erythrocyte and the erythrocyte membrane content of sialic acid and acid glycosaminoglycans (GAGs) were evaluated in insulin-dependent diabetic patients who had albumin excretion rates less than 300 mg/24 h. In these subjects a statistically significant reduction of erythrocyte anionic charge (RBCCh) and GAGs content in erythrocyte ghosts was shown. In view of the demonstration of a negative correlation between RBCCh and albuminuria after a lysine provocative test, these observations support the hypothesis that the onset of microalbuminuria in human diabetes is sustained by an alteration of glomerular charge and consequently of glomerular charge selectivity.

Citations

Apr 1, 1989·Diabetologia·T DeckertA Kofoed-Enevoldsen
Mar 1, 1991·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·G CandianoR Gusmano
Sep 16, 2003·Critical Care Medicine·Michael PiagnerelliMichel Vanhaeverbeek
Jun 16, 2006·Journal of Clinical Pathology·M PiagnerelliM Vanhaeverbeek
Oct 12, 2004·BMC Ophthalmology·Yasemin BudakDilek Yavuz
Oct 31, 2008·Journal of Biochemical and Molecular Toxicology·Serkan DegirmenciGüngör Kanbak
Mar 1, 1990·Diabetic Medicine : a Journal of the British Diabetic Association·G F Watts, D Pillay
Feb 10, 2020·The American Journal of Pathology·Matthew J ButlerSimon C Satchell

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