Abnormal expression of an ADAR2 alternative splicing variant in gliomas downregulates adenosine-to-inosine RNA editing

Acta neurochirurgica
Jun WeiYu Tian


RNA editing is catalyzed by adenosine deaminases acting on RNA (ADARs). ADAR2 is the main enzyme responsible for recoding editing in humans. Adenosine-to-inosine (A-to-I) editing at the Q/R site is reported to be decreased in gliomas; however, the expression of ADAR2 mRNA was not greatly affected. We determined ADAR2 mRNA expression in human glioblastoma cell lines and in normal human glial cells by real-time RT-PCR. We also determined ADAR2 mRNA expression in 44 glioma tissues and normal white matter. After identifying an alternative splicing variant (ASV) of ADAR2 in gliomas, we performed sequencing. We then classified glioblastomas based on the presence (+) or absence (-) of the ASV to determine the correlations between ASV + and malignant features of glioblastomas, such as invasion, peritumoral brain edema, and survival time. There were no significant differences in ADAR2 mRNA expression among human glioblastoma cell lines or in gliomas compared with normal white matter (all p > 0.05). The ASV, which contained a 47-nucleotide insertion in the ADAR2 mRNA transcript, was detected in the U251 and BT325 cell lines, and in some glioma tissues. The expression rate of ASV differed among gliomas of different grades. ASV + glioblast...Continue Reading


Jan 28, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hitoshi UchidaSeiji Ito
Sep 7, 2019·PloS One·Xiang WangYuanliang Yan
Apr 5, 2020·Cancers·Zhen Dong, Hongjuan Cui
Jul 26, 2016·Oncology Letters·Yao FuYu Tian


May 20, 1999·Nature·S M RueterRonald B Emeson
Nov 22, 2001·Proceedings of the National Academy of Sciences of the United States of America·Stefan MaasA Rich
Nov 10, 2004·PLoS Biology·Alekos AthanasiadisStefan Maas
Feb 22, 2005·Neoplasia : an International Journal for Oncology Research·Dominique B HoelzingerMichael E Berens
Sep 17, 2005·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Doga GurkanlarZeki Sekerci
Nov 23, 2006·RNA Biology·Stefan MaasKazuko Nishikura
Jul 27, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shogo IshiuchiSeiji Ozawa
Oct 3, 2007·Genome Research·Nurit PazGideon Rechavi
Sep 2, 2008·RNA Biology·Angela Gallo, Silvia Galardi
Jan 22, 2009·PloS One·Stefan Maas, Willemijn M Gommans
Mar 28, 2009·Developmental Neuroscience·Michelle M JacobsGregg D Stanwood
Aug 12, 2009·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Jozef SkardaGideon Rechavi
Sep 1, 2006·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Min-Woo ParkSuck-Jun Oh
Nov 13, 2009·International Journal of Cancer. Journal International Du Cancer·Federica GaleanoAngela Gallo
Mar 3, 2010·Annual Review of Biochemistry·Kazuko Nishikura
Mar 11, 2010·RNA Biology·Eli EisenbergErez Y Levanon
Oct 5, 2010·Critical Reviews in Oncology/hematology·Carlo BuonerbaJohn H Sampson
May 21, 2011·Science·Mingyao LiVivian G Cheung
Jun 21, 2011·Biological Reviews of the Cambridge Philosophical Society·Angela Gallo, Franco Locatelli
Jul 1, 2011·Carcinogenesis·Dan DominissiniGideon Rechavi
Sep 21, 2011·Seminars in Cell & Developmental Biology·Federica GaleanoAngela Gallo
Apr 20, 2012·Frontiers in Molecular Neuroscience·Amanda Wright, Bryce Vissel
Jul 13, 2012·Frontiers in Neuroscience·Aamira Tariq, Michael F Jantsch

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