Abnormal expression of ATP1A1 and ATP1A2 in breast cancer

F1000Research
Alexey BogdanovMichael Dubina

Abstract

Breast cancer is the first in incidence and the second in death among all solid tumors occurring in women. The identification of molecular genetic abnormalities in breast cancer is important to improve the results of treatment. In the present study, we analyzed microarray data of breast cancer expression profiling (NCBI GEO database, accession GSE65194), focusing on Na (+)/K (+)-ATPase coding genes. We found overexpression of the ATP1A1 and down-regulation of the ATP1A2. We expect that our research could help to improve the understanding of predictive and prognostic features of breast cancer.

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Citations

Dec 26, 2019·BMC Bioinformatics·Jianwei LuTianwei Yu
Apr 4, 2019·BMC Genomics·Alberto Berral-GonzalezGuillermo Ayala
Aug 14, 2021·Oncology Letters·Sophia C ThemistocleousIoannis Patrikios
Nov 26, 2021·Journal of Molecular Neuroscience : MN·Pablo Ferreira das ChagasElvis Terci Valera

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Datasets Mentioned

BETA
GSE65194

Software Mentioned

Expression Console
Transcriptome Analysis Console

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